Environmental signals controlling production of hemagglutinin/protease in Vibrio cholerae

被引：71
作者：
Benitez, JA
Silva, AJ
Finkelstein, RA
机构：
[1] Calif State Univ Fresno, Coll Sci & Math, Fresno, CA 93740 USA
[2] Univ Calif Davis, Sch Vet Med, Tulare, CA 93274 USA
[3] Vet Diagnost Lab, Tulare, CA 93274 USA
[4] Univ Missouri, Sch Med, Dept Mol Microbiol & Immunol, Columbia, MO 65212 USA
来源：
INFECTION AND IMMUNITY | 2001年 / 69卷 / 10期
关键词：
D O I：
10.1128/IAI.69.10.6549-6553.2001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Vibrio cholerae hemagglutinin/protease (Hap) was induced upon nutrient limitation and strongly repressed by glucose. Hap was not produced in a mutant defective in the cyclic AMP (cAMP) receptor protein, suggesting that intracellular cAMP levels mediate Hap expression. No difference was found in Hap production between an rpoS deletion mutant and its isogenic wild-type precursor, indicating that the alternate sigma (s) factor is not essential for Hap expression. Based on these and previous results, we discuss the role of Hap in the pathogenesis of cholera.
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页码：6549 / 6553
页数：5
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