Introducing PIONEER: a project to harness big data in prostate cancer research

被引：29

作者：

Omar, Muhammad Imran ^{[1
]}

Roobol, Monique J. ^{[2
]}

Ribal, Maria J. ^{[3
]}

Abbott, Thomas ^{[4
]}

Agapow, Paul-Michael ^{[5
]}

Araujo, Sonia ^{[6
]}

Asiimwe, Alex ^{[7
]}

Auffray, Charles ^{[8
]}

Balaur, Irina ^{[8
]}

Beyer, Katharina ^{[9
]}

Bernini, Chiara ^{[10
]}

Bjartell, Anders ^{[11
]}

Briganti, Alberto ^{[12
,13
]}

Butler-Ransohoff, John-Edward ^{[7
]}

Campi, Riccardo ^{[3
]}

Cavelaars, Marinel ^{[14
]}

De Meulder, Bertrand ^{[8
]}

Devecseri, Zsuzsanna ^{[15
]}

Voss, Marc Dietrich ^{[15
]}

Dimitropoulos, Konstantinos ^{[3
]}

Evans-Axelsson, Susan ^{[11
]}

Franks, Billy ^{[4
]}

Fullwood, Louise ^{[16
]}

Horgan, Denis ^{[10
]}

Smith, Emma Jane ^{[3
]}

Kiran, Amit ^{[4
]}

Kivinummi, Kati ^{[17
]}

Lambrecht, Mark ^{[18
]}

Lancet, Doron ^{[19
]}

Lindgren, Peter ^{[20
]}

MacLennan, Sara ^{[1
]}

MacLennan, Steven ^{[1
]}

Nogueira, Maria Manuela ^{[8
]}

Moen, Fredrik ^{[20
]}

Moinat, Maxim ^{[14
]}

Papineni, Kishore ^{[4
]}

Reich, Christian ^{[6
]}

Reiche, Kristin ^{[21
]}

Rogiers, Stijn ^{[18
]}

Sartini, Claudio ^{[7
]}

van Bochove, Kees ^{[14
]}

van Diggelen, Femke ^{[22
]}

Van Hemelrijck, Mieke ^{[9
]}

Van Poppel, Hein ^{[3
]}

Zong, Jihong ^{[7
]}

N'Dow, James ^{[3
]}

Andersson, Emelie ^{[20
]}

Arala, Heidi ^{[23
]}

Auvinen, Anssi ^{[17
]}

Bangma, Chris ^{[2
]}

机构：

[1] Univ Aberdeen, Acad Urol Unit, Aberdeen, Scotland

[2] Erasmus MC, Rotterdam, Netherlands

[3] European Assoc Urol, Guidelines Off, Arnhem, Netherlands

[4] Astellas, Leiden, Netherlands

[5] Imperial Coll London, London, England

[6] IQVIA, London, England

[7] Bayer AG, Berlin, Germany

[8] Assoc EISBM, Vourles, France

[9] Kings Coll London, Translat Oncol & Urol Res, London, England

[10] European Alliance Personalised Med EAPM, Brussels, Belgium

[11] Lund Univ, Dept Translat Med, Lund, Sweden

[12] Univ Vita Salute San Raffaele, IRCCS San Raffaele Sci Inst, Urol Res Inst, Dept Urol, Milan, Italy

[13] Univ Vita Salute San Raffaele, IRCCS San Raffaele Sci Inst, Urol Res Inst, Div Expt Oncol, Milan, Italy

[14] The Hyve, Utrecht, Netherlands

[15] Sanofi, Chilly Mazarin, France

[16] Pinsent Masons, Leeds, W Yorkshire, England

[17] Tampere Univ TAU, Tampere, Finland

[18] SAS, Tervuren, Belgium

[19] Weizmann Inst Sci, Rehovot, Israel

[20] Swedish Inst Hlth Econ IHE, Stockholm, Sweden

[21] Fraunhofer IZI, Leipzig, Germany

[22] Ttopstart, Utrecht, Netherlands

[23] Orion Corp, Espoo, Finland

[24] eCanc Global Fdn eGF eCanc, Bristol, Avon, England

[25] European Canc Patient Coalit ECPC, Brussels, Belgium

[26] Janssen Pharmaceut NV, Beerse, Belgium

[27] Goeteborgs Univ UGOT, Gothenburg, Sweden

[28] Tech Univ Dresden TUD, Dresden, Germany

[29] Radbound Univ, Med Ctr, Nijmegen, Netherlands

[30] European Org Res & Treatment Canc EORTC, Brussels, Belgium

[31] Univ Klinikum Hamburg Eppendorf UKE, Hamburg, Germany

来源：

NATURE REVIEWS UROLOGY | 2020年 / 17卷 / 06期

基金：

欧盟地平线“2020”;

关键词：

PATIENT-CENTERED OUTCOMES; RISK; MEN; SET; SURVEILLANCE;

D O I：

10.1038/s41585-020-0324-x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big data in prostate cancer, consisting of 32 private and public stakeholders from 9 countries across Europe. Launched by the Innovative Medicines Initiative 2 and part of the Big Data for Better Outcomes Programme (BD4BO), the overarching goal of PIONEER is to provide high-quality evidence on prostate cancer management by unlocking the potential of big data. The project has identified critical evidence gaps in prostate cancer care, via a detailed prioritization exercise including all key stakeholders. By standardizing and integrating existing high-quality and multidisciplinary data sources from patients with prostate cancer across different stages of the disease, the resulting big data will be assembled into a single innovative data platform for research. Based on a unique set of methodologies, PIONEER aims to advance the field of prostate cancer care with a particular focus on improving prostate-cancer-related outcomes, health system efficiency by streamlining patient management, and the quality of health and social care delivered to all men with prostate cancer and their families worldwide. Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big data in prostate cancer, consisting of 32 private and public stakeholders from 9 countries across Europe. In this Perspectives article, the authors introduce the PIONEER project and describe its aims and plans for ultimately improving prostate cancer care through the use of big data.

引用

页码：351 / 361

页数：11

共 48 条

[1] Characteristics of Prostate Cancer Found at Fifth Screening in the European Randomized Study of Screening for Prostate Cancer Rotterdam: Can We Selectively Detect High-grade Prostate Cancer with Upfront Multivariable Risk Stratification and Magnetic Resonance Imaging? [J].

Alberts, Arnout R. ;

Schoots, Ivo G. ;

Bokhorst, Leonard P. ;

Drost, Frank-Jan H. ;

van Leenders, Geert J. ;

Krestin, Gabriel P. ;

Dwarkasing, Roy S. ;

Barentsz, Jelle O. ;

Schroder, Fritz H. ;

Bangma, Chris H. ;

Roobol, Monique J. .

EUROPEAN UROLOGY, 2018, 73 (03) :343-350

[2]

[Anonymous], 2018, RWE in Europe Paper V: Policy Challenges around Real World Evidence Adoption in Europe

[3]

Auffray C, 2016, GENOME MED, V8, DOI [10.1186/s13073-016-0265-4, 10.1186/s13073-016-0323-y]

[4] A comparison of statistical methods for meta-analysis [J].

Brockwell, SE ;

Gordon, IR .

STATISTICS IN MEDICINE, 2001, 20 (06) :825-840

[5] Latest Evidence on the Impact of Smoking, Sports, and Sexual Activity as Modifiable Lifestyle Risk Factors for Prostate Cancer Incidence, Recurrence, and Progression: A Systematic Review of the Literature by the European Association of Urology Section of Oncological Urology (ESOU) [J].

Brookman-May, Sabine D. ;

Campi, Riccardo ;

Henriquez, Jose D. S. ;

Klatte, Tobias ;

Langenhuijsen, Johan F. ;

Brausi, Maurizio ;

Linares-Espinos, Estefania ;

Volpe, Alessandro ;

Marszalek, Martin ;

Akdogan, Bulent ;

Roll, Christina ;

Stief, Christian G. ;

Rodriguez-Faba, Oscar ;

Minervini, Andrea .

EUROPEAN UROLOGY FOCUS, 2019, 5 (05) :756-787

[6] Semantics in active surveillance for men with localized prostate cancer - results of a modified Delphi consensus procedure [J].

Bruinsma, Sophie M. ;

Roobol, Monique J. ;

Carroll, Peter R. ;

Klotz, Laurence ;

Pickles, Tom ;

Moore, Caroline M. ;

Gnanapragasam, Vincent J. ;

Villers, Arnauld ;

Rannikko, Antti ;

Valdagni, Riccardo ;

Frydenberg, Mark ;

Kakehi, Yoshiyuki ;

Filson, Christopher P. ;

Bangma, Chris H. .

NATURE REVIEWS UROLOGY, 2017, 14 (05) :312-+

[7] Impact of Metabolic Diseases, Drugs, and Dietary Factors on Prostate Cancer Risk, Recurrence, and Survival: A Systematic Review by the European Association of Urology Section of Oncological Urology [J].

Campi, Riccardo ;

Brookman-May, Sabine D. ;

Subiela Henriquez, Jose Daniel ;

Akdogan, Bulent ;

Brausi, Maurizio ;

Klatte, Tobias ;

Langenhuijsen, Johan F. ;

Linares-Espinos, Estefania ;

Marszalek, Martin ;

Roupret, Morgan ;

Stief, Christian G. ;

Volpe, Alessandro ;

Minervini, Andrea ;

Rodriguez-Faba, Oscar .

EUROPEAN UROLOGY FOCUS, 2019, 5 (06) :1029-1057

[8] Risk and presenting features of prostate cancer amongst African-Caribbean, South Asian and European men in North-east London [J].

Chinegwundoh, Frank ;

Enver, Mohamed ;

Lee, Angela ;

Nargund, Vinod ;

Oliver, Tim ;

Ben-Shlomo, Yoav .

BJU INTERNATIONAL, 2006, 98 (06) :1216-1220

[9] Geographical Variations in Prostate Cancer Outcomes: A Systematic Review of International Evidence [J].

Dasgupta, Paramita ;

Baade, Peter D. ;

Aitken, Joanne F. ;

Ralph, Nicholas ;

Chambers, Suzanne Kathleen ;

Dunn, Jeff .

FRONTIERS IN ONCOLOGY, 2019, 9

[10] A taxonomy has been developed for outcomes in medical research to help improve knowledge discovery [J].

Dodd, Susanna ;

Clarke, Mike ;

Becker, Lorne ;

Mavergames, Chris ;

Fish, Rebecca ;

Williamson, Paula R. .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 2018, 96 :84-92

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