This paper investigates the outage performance of cellular two-way amplify-and-forward (AF) cooperative spectrum sharing systems in the presence of primary user (PU) network and multiple secondary user (SU) destinations. A general Nakagami-m fading environment has been used, where distinct fading parameters, as well as unequal average fading powers between the interference and relaying links, are assumed. Focusing on the cooperation process among the SU nodes and making use of the underlay cognitive approach, an approximate closed-form expression for the overall outage probability (OOP) of the secondary network is derived. In this analysis, an opportunistic scheduling and transmit antenna selection (TAS) algorithm in the secondary network has been employed. Considering the interference constraints due to the presence of PU receiver, power allocation of secondary user is done. The effects of fading severity, secondary network relay placement, the number of PU & SU transmit antenna, and number of SUs on the end-to-end system performance are examined through some representative numerical plots. Moreover, to minimize the secondary network OOP, we investigate the optimization problems of relay position. Monte Carlo simulation results are presented to corroborate the proposed analysis. (C) 2018 Elsevier GmbH. All rights reserved.