First report of occult hepatitis B infection among ART naive HIV seropositive individuals in Maputo, Mozambique

被引:15
作者
Carimo, Awa Abdul [1 ]
Gudo, Eduardo Samo [2 ]
Maueia, Cremildo [2 ]
Mabunda, Nedio [2 ]
Chambal, Lucia [1 ]
Vubil, Adolfo [2 ]
Flora, Ana [2 ]
Antunes, Francisco [3 ]
Bhatt, Nilesh [2 ]
机构
[1] Maputo Cent Hosp, Internal Med Dept, Maputo, Mozambique
[2] Minist Hlth, Inst Nacl Saude, Maputo, Mozambique
[3] Univ Lisbon, Fac Med, Inst Saude Ambiental ISAMB, Lisbon, Portugal
来源
PLOS ONE | 2018年 / 13卷 / 01期
关键词
IMMUNODEFICIENCY-VIRUS COINFECTION; CORE ANTIGEN; POSITIVE PATIENTS; BLOOD-DONORS; PREVALENCE; AFRICA; RISK; REACTIVATION; ANTIBODIES; PATIENT;
D O I
10.1371/journal.pone.0190775
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background The prevalence of hepatitis B virus (HBV) infection and human immunodeficiency virus (HIV) infection in Mozambique is one of the highest in the world, though in spite of this the prevalence of occult hepatitis B infection (OBI) is unknown. Objectives This study was conducted with the aim to investigate the prevalence of OBI and frequency of isolated hepatitis B core antibody (anti-HBc alone) among antiretroviral (ART) naive HIV-positive patients in Mozambique. Methods A cross-sectional study was conducted in two health facilities within Maputo city. All ART-naive HIV seropositive patients attending outpatient clinics between June and October 2012 were consecutively enrolled. Blood samples were drawn from each participant and used for serological measurement of HBV surface antigen (HBsAg), antibodies against HBV surface antigen (anti-HBs) and antibodies against core antigen (anti-HBc) using ELISA. Quantification of HBV DNA was performed by real time PCR. A questionnaire was used to obtain demographics and clinical data. Results Of the 518 ART-naive HIV-positive subjects enrolled in the study, 90.9% (471/518) were HBsAg negative. Among HBsAg negative, 45.2% (213/471) had isolated anti-HBc antibodies, and the frequency of OBI among patients with anti-HBc alone was 8.3% (17/206). OBI was not correlated either with CD4(+) T cells count or transaminases levels. A total of 11.8% of patients with OBI presented elevated HBV DNA level. Frequency of individuals with APRI score > 2 and FIB-4 score > 3.25 was higher in patients with OBI as compared not exposed, immune and anti-HBc alone patients. Conclusion Our data demonstrate for the first time that OBI is prevalent among HIV patients in Mozambique, and will be missed using the commonly available serological assays that measures HBsAg.
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