Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline

被引：502

作者：

Ballinger, Elizabeth C. ^{[1
]}

Ananth, Mala ^{[2
]}

Talmage, David A. ^{[3
]}

Role, Lorna W. ^{[4
]}

机构：

[1] SUNY Stony Brook, Dept Neurobiol & Behav, Med Scientist Training Program, Program Neurosci, Stony Brook, NY 11794 USA

[2] SUNY Stony Brook, Dept Neurobiol & Behav, Dept Psychiat & Behav Sci, Program Neurosci, Stony Brook, NY 11794 USA

[3] SUNY Stony Brook, Ctr Mol Med, CNS Disorders Ctr, Dept Pharmacol Sci, Stony Brook, NY 11794 USA

[4] SUNY Stony Brook, Ctr Mol Med, CNS Disorders Ctr, Neurosci Inst,Dept Neurobiol & Behav, Stony Brook, NY 11794 USA

来源：

NEURON | 2016年 / 91卷 / 06期

关键词：

NICOTINIC ACETYLCHOLINE-RECEPTORS; HIPPOCAMPAL SYNAPTIC PLASTICITY; MEDIAL PREFRONTAL CORTEX; CENTRAL-NERVOUS-SYSTEM; PARKINSONS-DISEASE DEMENTIA; LATENCY AFFERENT INHIBITION; ALZHEIMERS-DISEASE; IN-VIVO; AMYLOID-BETA; BRAIN-STEM;

D O I：

10.1016/j.neuron.2016.09.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent work continues to place cholinergic circuits at center stage for normal executive and mnemonic functioning and provides compelling evidence that the loss of cholinergic signaling and cognitive decline are inextricably linked. This Review focuses on the last few years of studies on the mechanisms by which cholinergic signaling contributes to circuit activity related to cognition. We attempt to identify areas of controversy, as well as consensus, on what is and is not yet known about how cholinergic signaling in the CNS contributes to normal cognitive processes. In addition, we delineate the findings from recent work on the extent to which dysfunction of cholinergic circuits contributes to cognitive decline associated with neurodegenerative disorders.

引用

页码：1199 / 1218

页数：20

共 200 条

[1] Role of cholinesterase inhibitors in Parkinson's disease and dementia with Lewy bodies [J].