Virus-host interactomes and global models of virus-infected cells

被引：48
作者：
Friedel, Caroline C. [2 ,3 ]
Haas, Juergen [1 ,4 ]
机构：
[1] Univ Edinburgh, Div Pathway Med & Edinburgh Infect Dis, Edinburgh EH16 4SB, Midlothian, Scotland
[2] Heidelberg Univ, Inst Pharm & Mol Biotechnol, D-69120 Heidelberg, Germany
[3] Univ Munich, Inst Informat, D-80333 Munich, Germany
[4] Univ Munich, Max Von Pettenkofer Inst, D-80336 Munich, Germany
来源：
TRENDS IN MICROBIOLOGY | 2011年 / 19卷 / 10期
基金：
英国医学研究理事会;
关键词：
PROTEIN-PROTEIN INTERACTIONS; EPSTEIN-BARR-VIRUS; WEST-NILE-VIRUS; CELLULAR COFACTORS; SCREEN; MAP; IDENTIFICATION; HIV-1; ESSENTIALITY; CENTRALITY;
D O I：
10.1016/j.tim.2011.07.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Novel high-throughput technologies such as yeast two-hybrid and RNA interference (RNAi) screens provide the tools to study interactions between viral proteins and the host on a genomic scale. In this review, we provide an overview of studies in which these technologies were applied and cif computational approaches for the analysis of the identified viral interactors in the context of the host cell. The results of these studies illustrate the advantages cif integrative systems biology approaches in the investigation of viral pathogens.
引用
收藏
页码：501 / 508
页数：8
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