'Poppy seeds' in stomach aspirates: is oral omeprazole extemporaneous dispersion bioavailable?

被引：8

作者：

Tuleu, Catherine ^{[1
,2
]}

Arenas-Lopez, Sara ^{[3
]}

Robinson, Chris ^{[3
]}

McCarthy, David ^{[4
]}

Paget, Richard I. J. ^{[5
]}

Tibby, Shane ^{[5
]}

Taylor, Kevin M. G. ^{[1
]}

机构：

[1] Univ London, Sch Pharm, Dept Pharmaceut, London WC1N 1AX, England

[2] Univ London, Sch Pharm, Ctr Paediat Pharm Res, London WC1N 1AX, England

[3] Evelina Childrens Hosp, Dept Pharm, Guys & St Thomas NHS Fdn Trust, London, England

[4] Univ London, Sch Pharm, Electron Microscopy Unit, London WC1N 1AX, England

[5] Evelina Childrens Hosp, Paediat Intens Care Unit, Guys & St Thomas NHS Fdn Trust, London, England

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 2008年 / 167卷 / 07期

关键词：

liquid omeprazole; paediatric administration; extemporaneous disperson in water; degradation;

D O I：

10.1007/s00431-007-0567-z

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report the appearance of 'poppy seed'-like structures found in the aspirated stomach contents and faeces of a 3-month-old infant receiving an omeprazole liquid via nasogastric tube, prepared by dispersing an omeprazole tablet (10 mg MUPS (R)) in water. Electron microscopy and mass spectroscopy indicated that these particles were hollow, dark purple coloured spheres comprising undissolved omeprazole and its degradation products. These observations suggest rapid degradation of omeprazole in the acid stomach contents, with compromised absorption of active drug. Consequently, dispersion of omeprazole in water may be an inappropriate formulation in this setting.

引用

页码：823 / 825

页数：3

共 4 条

[1] Use of unlicensed and off-label medications in paediatric gastroenterology with a review of the commonly used formularies in the UK [J].