Differential influence of interleukin-12 in the pathogenesis of autoimmune and virus-induced central nervous system demyelination

被引：33
作者：
Bright, JJ
Rodriguez, M
Sriram, S
机构：
[1] Vanderbilt Univ, Med Ctr, Multiple Sclerosis Res Lab, Nashville, TN 37212 USA
[2] Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN 55905 USA
[3] Mayo Clin & Mayo Fdn, Dept Immunol, Rochester, MN 55905 USA
来源：
JOURNAL OF VIROLOGY | 1999年 / 73卷 / 02期
关键词：
D O I：
10.1128/JVI.73.2.1637-1639.1999
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) disease are hire demyelinating diseases of the central nervous system (CNS) that serve as animal models for multiple sclerosis. Th1 cells are thought to play a role in the pathogenesis of CNS demyelination in both these diseases. We show here the differential influence of interleukin 12, a critical cytokine for the development of Th1 cells in EAE and TMEV disease.
引用
收藏
页码：1637 / 1639
页数：3
相关论文
共 14 条
[1]  
BORROW P, 1993, IMMUNOLOGY, V80, P502
[2]   Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis [J].
Bright, JJ ;
Musuro, BF ;
Du, C ;
Sriram, S .
JOURNAL OF NEUROIMMUNOLOGY, 1998, 82 (01) :22-30
[3]   Antiviral immune responses modulate the nature of central nervous system (CNS) disease in a murine model of multiple sclerosis [J].
Drescher, KM ;
Pease, LR ;
Rodriguez, M .
IMMUNOLOGICAL REVIEWS, 1997, 159 :177-193
[4]   PREVENTION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS BY ANTIBODIES AGAINST INTERLEUKIN-12 [J].
LEONARD, JP ;
WALDBURGER, KE ;
GOLDMAN, SJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (01) :381-386
[5]   Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading [J].
Miller, SD ;
Vanderlugt, CL ;
Begolka, WS ;
Pao, W ;
Yauch, RL ;
Neville, KL ;
KatzLevy, Y ;
Carrizosa, A ;
Kim, BS .
NATURE MEDICINE, 1997, 3 (10) :1133-1136
[6]   CD4+ and CD8+ T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis [J].
Murray, PD ;
Pavelko, KD ;
Leibowitz, J ;
Lin, X ;
Rodriguez, M .
JOURNAL OF VIROLOGY, 1998, 72 (09) :7320-7329
[7]   Theiler's virus persistence and demyelination in major histocompatibility complex class II-deficient mice [J].
Njenga, MK ;
Pavelko, KD ;
Baisch, J ;
Lin, XQ ;
David, C ;
Leibowitz, J ;
Rodriguez, M .
JOURNAL OF VIROLOGY, 1996, 70 (03) :1729-1737
[8]   THE IMMUNOLOGY OF MULTIPLE-SCLEROSIS AND ITS ANIMAL-MODEL, EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS [J].
OWENS, T ;
SRIRAM, S .
NEUROLOGIC CLINICS, 1995, 13 (01) :51-73
[9]   SPLIT TOLERANCE OF T(H)1 AND T(H)2 CELLS IN TOLERANCE TO THEILER MURINE ENCEPHALOMYELITIS VIRUS [J].
PETERSON, JD ;
KARPUS, WJ ;
CLATCH, RJ ;
MILLER, SD .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (01) :46-55
[10]  
PIERCE M, 1989, J HISTOTECHNOL, V12, P35
12