A case of IgA kappa light chain deposition disease and combined adult Fanconi syndrome with auer rod-like intracytoplasmic inclusions in plasma cells and proximal renal tubular cells

被引：1
作者：
Kahng, Jimin [1 ]
Kim, Jeana [2 ]
Shin, Suk Joon [3 ]
Han, Kyungja [1 ]
机构：
[1] Catholic Univ Korea, Coll Med, Dept Lab Med, Seoul, South Korea
[2] Catholic Univ Korea, Coll Med, Dept Hosp Pathol, Seoul, South Korea
[3] Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea
来源：
KOREAN JOURNAL OF LABORATORY MEDICINE | 2007年 / 27卷 / 04期
关键词：
Auer rod-like inclusion; light chain deposition disease; Fanconi syndrome; MULTIPLE-MYELOMA; MONOCLONAL GAMMOPATHIES; INTRACELLULAR CRYSTALS; FEATURES;
D O I：
10.3343/kjlm.2007.27.4.248
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
We report a case of IgA kappa light chain deposition disease and combined adult Fanconi syndrome with Auer rod-like intracytoplasmic inclusions in plasma cells and proximal renal tubular cells in a 54-yr-old female. Cytochemical stainings revealed a strong acid phosphatase activity of the inclusions and weak periodic acid-Schiff positivity, whereas the reactions for peroxidase and alpha-naphthyl acetate esterase were negative. An immunostaining verified IgA-kappa inside the plasma cells. Kidney biopsy revealed Bence Jones cast nephropathy with kappa light chain positivity, and Congo red staining was negative. Electron microscopy showed needle-shaped crystals located in tubular epithelial cells.
引用
收藏
页码：248 / 252
页数：5
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