N-D-Aldopentofuranosyl-N′-[p-(isoamyloxy)phenyl]-thiourea derivatives:: Potential anti-TB therapeutic agents

被引：46

作者：

Liav, Avraham ^{[1
]}

Angala, Shiva K. ^{[1
]}

Brennan, Patrick J. ^{[1
]}

Jackson, Mary ^{[1
]}

机构：

[1] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 08期

关键词：

thiocarlide; thiourea; isoxyl; Mycobacterium tuberculosis;

D O I：

10.1016/j.bmcl.2008.03.033

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Thiocarlide (THC; N,N'-bis[p-(isoamyloxy)phenyl]-thiourea; also known as isoxyl) has been used in the past as antituberculosis agent. In an effort to improve the therapeutic value of THC several N-pentofuranosyl-N'-[p-(isoamyloxy)phenyl]-thiourea derivatives were synthesized by coupling of an aniline derivative and pentofuranosyl isothiocyanates. The MIC values of the new products against M. tb indicate that this new approach to the synthesis of potential anti-TB therapeutic agents was successful. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2649 / 2651

页数：3

共 13 条

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