Isolation, structural identification and biological characterization of two conopeptides from the Conus pennaceus venom

被引：5

作者：

Abdel-Wahab, Mohammed ^{[1
,2
]}

Miyashita, Masahiro ^{[2
]}

Ota, Yoshiyuki ^{[2
]}

Juichi, Hironori ^{[2
]}

Okabe, Ryota ^{[2
]}

Sarhan, Moustafa ^{[1
]}

Fouda, Maged ^{[1
]}

Abdel-Rahman, Mohamed ^{[3
]}

Saber, Samy ^{[4
]}

Nakagawa, Yoshiaki ^{[2
]}

机构：

[1] Al Azhar Univ, Zool Dept, Assiut, Egypt

[2] Kyoto Univ, Grad Sch Agr, Kyoto, Japan

[3] Suez Canal Univ, Zool Dept, Ismailia, Egypt

[4] Al Azhar Univ, Zool Dept, Cairo, Egypt

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2017年 / 81卷 / 11期

关键词：

cone snail; venom; peptide toxin; anti-mollusk toxicity; mass spectrometry; CHANNEL-BLOCKING CONOTOXINS;

D O I：

10.1080/09168451.2017.1364966

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel anti-mollusk conopeptide pn4c was isolated from the Conus pennaceus venom by repeated HPLC fractionation based on the activity against freshwater snails. The primary structure of pn4c was determined by the mass spectrometric de novo sequencing analysis. In addition, pn3a was isolated from the same fraction containing pn4c, as a peptide with unknown functions.

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收藏

页码：2086 / 2089

页数：4

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