Total NMR assignment of a new antiproliferative triterpene oligoglycoside from the sea cucumber Astichopus multifidus

被引：4

作者：

Graniel-Sabido, Manlio J. ^{[1
]}

Miron-Lopez, Gumersindo ^{[1
]}

Leon-Deniz, Lorena V. ^{[2
]}

Moo-Puc, Rosa E. ^{[3
]}

Quintal-Novelo, Carlos J. ^{[4
]}

Quijano, Leovigildo ^{[5
]}

Mena-Rejon, Gonzalo J. ^{[1
]}

机构：

[1] Univ Autonoma Yucatan, Fac Quim, C 43 613 X C 90 Col Inalambrica, Merida 97069, Yucatan, Mexico

[2] Univ Autonoma Yucatan, Fac Med Vet & Zootecnia, Carr Xmatkuil,Km 15-5,Apartado Postal 116, Merida 97315, Yucatan, Mexico

[3] IMSS, Ctr Med Ignacio Garcia Tellez, Unidad Med Alta Especialidad, Unidad Invest Med Yucatan, C 41,439, Merida 97150, Yucatan, Mexico

[4] IMSS, Ctr Med Ignacio Garcia Tellez, Unidad Med Alta Especialidad, C 41,439, Merida 97150, Yucatan, Mexico

[5] Univ Nacl Autonoma Mexico, Inst Quim, Circuito Exterior,Ciudad Univ, Mexico City 04510, DF, Mexico

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 39期

关键词：

NMR; 1D-TOCSY; Triterpene oligoglycosides; Astichopus multifidus; Antiproliferative activity; Breast cancer; COMPONENTS; GLYCOSIDES; TOCSY;

D O I：

10.1016/j.tetlet.2016.08.051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Astichoposide D, a new oligoglycosidic triterpene of the holostan-type was isolated from Astichopus multifidus together with the known astichoposide C and Sticholoroside B-2. The structure elucidation and the complete assignment of all signals of the compounds were accomplished based on 1D and 2D, H-1, and C-13 NMR experiments, mainly on the 1D TOCSY experiment with different mixed times. The antiproliferative activity of isolated compounds against two breast cancer cell lines (MCF-7 and MDA-MB-231) was investigated. All compounds exhibited antiproliferative activity against both breast cancer cells ranging from 5.53 to 1.38 mu M. (C) 2016 Published by Elsevier Ltd.

引用

页码：4375 / 4378

页数：4

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