Molecular pathophysiology of chronic pancreatitis -: An update

被引：8
|
作者：
Friess, H [1 ]
Kleeff, J [1 ]
Büchler, MW [1 ]
机构：
[1] Univ Heidelberg, Dept Gen Surg, D-69120 Heidelberg, Germany
来源：
JOURNAL OF GASTROINTESTINAL SURGERY | 2003年 / 7卷 / 08期
关键词：
D O I：
10.1016/j.gassur.2003.10.002
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The pathogenesis of chronic pancreatitis is still not completely understood. However, recent advances in cellular and molecular biology have revealed complex interactions between in.ammatory cells and pancreatic parenchyma cells, as well as alterations in nerves. Furthermore, as a result of novel technologies, it has become possible to identify key genes in the disease process of chronic pancreatitis. Tryptase,15 CRISP3,16 and COMP17 are three of the candidate genes that may serve as disease markers and therapeutic targets in the future. Further molecular and cell biology studies will increase our knowledge of the pathogenesis and pathophysiology of this disease, hopefully resulting in better diagnostic and therapeutic modalities in the future.
引用
收藏
页码：943 / 945
页数：3
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