Molecular pathophysiology of chronic pancreatitis -: An update

被引：8
|
作者：
Friess, H [1 ]
Kleeff, J [1 ]
Büchler, MW [1 ]
机构：
[1] Univ Heidelberg, Dept Gen Surg, D-69120 Heidelberg, Germany
来源：
JOURNAL OF GASTROINTESTINAL SURGERY | 2003年 / 7卷 / 08期
关键词：
D O I：
10.1016/j.gassur.2003.10.002
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The pathogenesis of chronic pancreatitis is still not completely understood. However, recent advances in cellular and molecular biology have revealed complex interactions between in.ammatory cells and pancreatic parenchyma cells, as well as alterations in nerves. Furthermore, as a result of novel technologies, it has become possible to identify key genes in the disease process of chronic pancreatitis. Tryptase,15 CRISP3,16 and COMP17 are three of the candidate genes that may serve as disease markers and therapeutic targets in the future. Further molecular and cell biology studies will increase our knowledge of the pathogenesis and pathophysiology of this disease, hopefully resulting in better diagnostic and therapeutic modalities in the future.
引用
收藏
页码：943 / 945
页数：3
相关论文
共 50 条
  • [31] ACUTE AND CHRONIC-PANCREATITIS - AN UPDATE ON MANAGEMENT
    LANKISCH, PG
    DRUGS, 1984, 28 (06) : 554 - 564
  • [32] Chronic pancreatitis: an update on genetic risk factors
    Weiss, Frank U.
    Skube, Mariya E.
    Lerch, Markus M.
    CURRENT OPINION IN GASTROENTEROLOGY, 2018, 34 (05) : 322 - 329
  • [33] Update of exocrine functional diagnostics in chronic pancreatitis
    Nojgaard, Camilla
    Olesen, Soren Schou
    Frokjaer, Jens Brondum
    Drewes, Asbjorn Mohr
    CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, 2013, 33 (03) : 167 - 172
  • [34] Molecular mechanisms in chronic pancreatitis
    Esposito, I
    Friess, H
    Büchler, MW
    ZENTRALBLATT FUR CHIRURGIE, 2001, 126 (11): : 867 - 872
  • [35] Molecular basis of chronic pancreatitis
    Bernard, JP
    RECENT ADVANCES IN THE PATHOPHYSIOLOGY OF GASTRO-INTESTINAL AND LIVER DISEASES, 1997, : 185 - 192
  • [36] Chronic pruritus: update on pathophysiology, guidelines and innovate treatments
    Zeidler, Claudia
    Pereira, Manuel P.
    DERMATOLOGIE, 2022, 73 (08): : 591 - 592
  • [37] Chronic fatigue syndrome: an update focusing on phenomenology and pathophysiology
    Cho, HJ
    Skowera, A
    Cleare, A
    Wessely, S
    CURRENT OPINION IN PSYCHIATRY, 2006, 19 (01) : 67 - 73
  • [38] Molecular pathophysiology of chronic myelogenous leukemia
    Turhan, AG
    Solary, E
    Vainchenker, W
    Dusanter-Fourt, I
    HEMATOLOGY AND CELL THERAPY, 1998, 40 (05) : 217 - 221
  • [39] Incontinentia pigmenti: A review and update on the molecular basis of pathophysiology
    Berlin, AL
    Paller, AS
    Chan, LS
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2002, 47 (02) : 169 - 187
  • [40] 50 Years of Progress in Pathophysiology, Diagnosis and Treatment of Chronic Pancreatitis
    Lerch, M. M.
    Mayerle, J.
    ZEITSCHRIFT FUR GASTROENTEROLOGIE, 2013, 51 (04): : 358 - 362
12345