Conformational Structure of Tyrosine, Tyrosyl-glycine, and Tyrosyl-glycyl-glycine by Double Resonance Spectroscopy

被引：51

作者：

Abo-Riziq, Ali ^{[1
]}

Grace, Louis ^{[1
]}

Crews, Bridgit ^{[1
]}

Callahan, Michael P. ^{[1
]}

van Mourik, Tanja ^{[2
]}

de Vries, Mattanjah S. ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

[2] Univ St Andrews N Haugh, EaStCHEM Sch Chem, St Andrews KY16 9ST, Fife, Scotland

来源：

JOURNAL OF PHYSICAL CHEMISTRY A | 2011年 / 115卷 / 23期

基金：

美国国家科学基金会;

关键词：

DESORPTION-VOLATILIZATION METHOD; QUANTUM-CHEMICAL CALCULATIONS; AB-INITIO CALCULATIONS; AMINO-ACID TRYPTOPHAN; ION-DIP SPECTROSCOPY; GAS-PHASE; SUPERSONIC JET; ELECTRONIC SPECTROSCOPY; LASER SPECTROSCOPY; MOLECULAR-BEAM;

D O I：

10.1021/jp110601w

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We investigated the variation in conformation for the amino acid tyrosine (Y), alone and in the small peptides tyrosine-glycine (YG) and tyrosine-glycine-glycine (YGG), in the gas phase by using UV-UV and IR-UV double resonance spectroscopy and density functional theory calculations. For tyrosine we found seven different conformations, for YG we found four different conformations, and for YGG we found three different conformations. As the peptides get larger, we observe fewer stable conformers, despite the increasing complexity and number of degrees of freedom. We find structural trends similar to those in phenylalanine-glycine-glycine (FGG) and tryptophan-glycine-glycine (WGG); however, the effect of dispersive forces in FGG for stabilizing a folded structure is replaced by that of hydrogen bonding in YGG.

引用

页码：6077 / 6087

页数：11