Data Platform for the Research and Prevention of Alzheimer's Disease

被引：1

作者：

An, Ning ^{[1
]}

Jin, Liuqi ^{[1
]}

Yang, Jiaoyun ^{[1
]}

Yin, Yue ^{[1
]}

Jiang, Siyuan ^{[1
]}

Jing, Bo ^{[1
]}

Au, Rhoda ^{[2
]}

机构：

[1] Hefei Univ Technol, Sch Comp & Informat, 193 Tunxi Rd, Hefei 230009, Anhui, Peoples R China

[2] Boston Univ, Sch Med, 72 E Concord St, Boston, MA 02118 USA

来源：

HEALTHCARE AND BIG DATA MANAGEMENT | 2017年 / 1028卷

基金：

中国国家自然科学基金;

关键词：

Data platform; Alzheimer's disease; Implementation; DISCOVERY; HEALTH; RISK; AD;

D O I：

10.1007/978-981-10-6041-0_4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

With the rapid increase in global aging, Alzheimer's disease has become a major burden in both social and economic costs. Substantial resources have been devoted to researching this disease, and rich multimodal data resources have been generated. In this chapter, we discuss an ongoing effort to build a data platform to harness these data to help research and prevention of Alzheimer's disease. We will detail this data platform in terms of its architecture, its data integration strategy, and its data services. Then, we will consider how to leverage this data platform to accelerate risk factor identification and pathogenesis study with its data analytics capability. This chapter will provide a concrete pathway for developing a data platform for studying and preventing insidious onset chronic diseases in this data era.

引用

页码：55 / 78

页数：24

共 39 条

[1] 2018 Alzheimer's disease facts and figures [J].

不详 .

ALZHEIMERS & DEMENTIA, 2018, 14 (03) :367-425

[2] A Self-Report Risk Index to Predict Occurrence of Dementia in Three Independent Cohorts of Older Adults: The ANU-ADRI [J].

Anstey, Kaarin J. ;

Cherbuin, Nicolas ;

Herath, Pushpani M. ;

Qiu, Chengxuan ;

Kuller, Lewis H. ;

Lopez, Oscar L. ;

Wilson, Robert S. ;

Fratiglioni, Laura .

PLOS ONE, 2014, 9 (01)

[3] Amyloid-β and Tau The Trigger and Bullet in Alzheimer Disease Pathogenesis [J].

Bloom, George S. .

JAMA NEUROLOGY, 2014, 71 (04) :505-508

[4]

Centers for Disease Control and Prevention, 2014, OBES CHILDR AD AG, P2

[5] The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data [J].

Cerami, Ethan ;

Gao, Jianjiong ;

Dogrusoz, Ugur ;

Gross, Benjamin E. ;

Sumer, Selcuk Onur ;

Aksoy, Buelent Arman ;

Jacobsen, Anders ;

Byrne, Caitlin J. ;

Heuer, Michael L. ;

Larsson, Erik ;

Antipin, Yevgeniy ;

Reva, Boris ;

Goldberg, Arthur P. ;

Sander, Chris ;

Schultz, Nikolaus .

CANCER DISCOVERY, 2012, 2 (05) :401-404

[6]

CommonMind Consortium Launched as a Public-Private Effort to Generate and Broadly Share Molecular Data on Neuropsychiatric Disease, 2012, BIOM MARK NEWSL

[7]

Day KL, 2009, GENERATIONS, V33, P11

[8] Machine Learning-Based Method for Personalized and Cost-Effective Detection of Alzheimer's Disease [J].

Escudero, Javier ;

Ifeachor, Emmanuel ;

Zajicek, John P. ;

Green, Colin ;

Shearer, James ;

Pearson, Stephen .

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2013, 60 (01) :164-168

[9] Midlife risk score for the prediction of dementia four decades later [J].

Exalto, Lieza G. ;

Quesenberry, Charles P. ;

Barnes, Deborah ;

Kivipelto, Miia ;

Biessels, Geert Jan ;

Whitmer, Rachel A. .

ALZHEIMERS & DEMENTIA, 2014, 10 (05) :562-570

[10] THE RICIAN DISTRIBUTION OF NOISY MRI DATA [J].

GUDBJARTSSON, H ;

PATZ, S .

MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (06) :910-914

← 1 2 3 4 →