Synthesis, characterization and biological activity of triorganotin 2-phenyl-1,2,3-triazole-4-carboxylates

被引：117

作者：

Tian, LJ ^{[1
]}

Sun, YX

Li, HJ

Zheng, XL

Cheng, YZ

Liu, XL

Qian, BH

机构：

[1] Qufu Normal Univ, Dept Chem, Qufu 273165, Peoples R China

[2] Zhejiang Acad Med Sci, Inst Mat Med, Hangzhou 310013, Peoples R China

[3] Zhejiang Univ City Coll, Inst Mat ed, Hangzhou 310015, Peoples R China

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2005年 / 99卷 / 08期

关键词：

organotin carboxylate; 2-phenyl-1,2,3-triazole-4-carboxylic acid; antibacterial activity; antitumor activity; crystal structure;

D O I：

10.1016/j.jinorgbio.2005.05.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The triorganotin 2-phenyl-1,2,3-triazole-4-carboxylates, 2-PhC2N3CO2SnR3 (R = C6H5, 1; c-C6H11, 2; C6H5C(CH3)(2)CH2, 3), have been prepared and characterized by means of elemental analysis, IR and NMR (H-1, C-13 and Sn-119) spectroscopy. The crystal structures of 1 and 3 have been determined. Compound 1 is polymeric in nature with a trigonal bipyramidal configuration, and compound 3 shows a tetrahedral geometry. Bioassay results have shown that these compounds have good antibacterial and antitumor activity. The activity against three human tumor cell lines (HeLa, CoLo205 and MCF-7) decreased in the order I > 2 > 3. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1646 / 1652

页数：7

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