The El Escorial criteria: Strengths and weaknesses

被引：62

作者：

Agosta, Federica ^{[1
,2
]}

Al-Chalabi, Ammar ^{[3
]}

Filippi, Massimo ^{[1
,2
]}

Hardiman, Orla ^{[5
]}

Kaji, Ryuji ^{[6
]}

Meininger, Vincent ^{[7
]}

Nakano, Imaharu ^{[8
]}

Shaw, Pamela ^{[9
]}

Shefner, Jeremy ^{[10
]}

van den Berg, Leonard H. ^{[11
]}

Ludolph, Albert ^{[4
]}

机构：

[1] Univ Vita Salute San Raffaele, Milan, Italy

[2] Ist Sci San Raffaele, I-20132 Milan, Italy

[3] Kings Coll London, KHP Ctr Neurodegenerat Res, Dept Clin Neurosci, London WC2R 2LS, England

[4] Univ Ulm, Dept Neurol, D-89075 Ulm, Germany

[5] Univ Dublin Trinity Coll, Trinity Biomed Sci Inst, Dublin 2, Ireland

[6] Tokushima Univ Hosp, Inst Hlth Biosci, Dept Clin Neurosci, Dept Neurol, Tokushima, Japan

[7] Hop La Pitie Salpetriere, Ctr Referent Malad Rares SLA, Paris, France

[8] Jichi Med Univ, Dept Neurol, Shimotsuke, Tochigi, Japan

[9] Univ Sheffield, Acad Neurol, Sheffield S10 2TN, S Yorkshire, England

[10] SUNY Upstate Med Univ, Syracuse, NY 13210 USA

[11] Univ Med Ctr Utrecht, Dept Neurol, Utrecht, Netherlands

来源：

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION | 2015年 / 16卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

ALS; El Escorial; AMYOTROPHIC-LATERAL-SCLEROSIS; MOTOR-NEURON DISEASE; HEXANUCLEOTIDE REPEAT; DIAGNOSTIC-CRITERIA; RANDOMIZED-TRIAL; AWAJI CRITERIA; ADULT-ONSET; ALS; INVOLVEMENT; INDIVIDUALS;

D O I：

10.3109/21678421.2014.964258

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis (ALS) were established 20 years ago and have been used as inclusion criteria for clinical trials. However, concerns have been raised concerning their use as diagnostic criteria in clinical practice. Moreover, as modern genetics have shed new light on the heterogeneity of ALS and the close relationship between ALS and frontotemporal dementia (FTD) recognized, the World Federation of Neurology Research Group on ALS/MND has initiated discussions to amend and update the criteria, while preserving the essential components for clinical trial enrolment purposes.

引用

页码：1 / 7

页数：7

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