Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support

被引：31

作者：

Paterson, I ^{[1
]}

Gottschling, D ^{[1
]}

Menche, D ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 28期

关键词：

D O I：

10.1039/b505746a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

By relying on asymmetric boron-mediated aldol reactions, solid phase methodology for the stereoselective synthesis of highly substituted spiroacetals was developed and applied to the preparation of a complex AB-spiroacetal subunit of the antimitotic agent spongistatin 1 ( altohyrtin A).

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页码：3568 / 3570

页数：3

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