Influence of early phase clinical trial enrollment on patterns of end-of-life care for children with advanced cancer

被引：10

作者：

Ananth, Prasanna ^{[1
]}

Monsereenusorn, Chalinee ^{[2
]}

Ma, Clement ^{[1
]}

Al-Sayegh, Hasan ^{[1
]}

Wolfe, Joanne ^{[1
,3
]}

Rodriguez-Galindo, Carlos ^{[4
]}

机构：

[1] Dana Farber Boston Childrens Canc & Blood Disorde, Dept Pediat Hematol Oncol, Boston, MA USA

[2] Phramongkutklao Hosp & Coll Med, Dept Pediat, Bangkok, Thailand

[3] Dana Farber Canc Inst, Dept Psychosocial Oncol & Palliat Care, Boston, MA 02115 USA

[4] St Jude Childrens Res Hosp, Dept Global Pediat Med, 332 N Lauderdale St, Memphis, TN 38105 USA

来源：

PEDIATRIC BLOOD & CANCER | 2018年 / 65卷 / 01期

关键词：

early phase clinical trials; end-of-life care; PALLIATIVE CARE; ONCOLOGY TRIALS; I TRIALS; PARTICIPATION; BENEFITS; THERAPY; RISKS;

D O I：

10.1002/pbc.26748

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We conducted a retrospective cohort study of 125 pediatric oncology patients who died in 2010-2014 to explore how healthcare utilization, pediatric palliative care (PPC) receipt, and end-of-life care (EOLC) differed between patients enrolled in early phase clinical trials (EP) and those not enrolled (NEP). Baseline characteristics and healthcare utilization did not significantly differ between groups. EP patients received PPC consultation closer to death than NEP patients (median days before death = 58 [interquartile range = 16-84] vs. 85 [32-173]; P = 0.04). Our findings suggest that early phase trial enrollment does not substantially alter EOLC for children with advanced cancer but may contribute to later PPC engagement. Future studies should definitively assess the relationship between trial enrollment and PPC timing.

引用

页数：4

共 20 条

[1] Ethics of phase 1 oncology studies - Reexamining the arguments and data [J].

Agrawal, M ;

Emanuel, EJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (08) :1075-1082

[2]

Barrera Maru, 2005, Palliat Support Care, V3, P191

[3] ONCOLOGISTS RELUCTANCE TO ACCRUE PATIENTS ONTO CLINICAL-TRIALS - AN ILLINOIS CANCER CENTER STUDY [J].

BENSON, AB ;

PREGLER, JP ;

BEAN, JA ;

RADEMAKER, AW ;

ESHLER, B ;

ANDERSON, K .

JOURNAL OF CLINICAL ONCOLOGY, 1991, 9 (11) :2067-2075

[4] Understanding parents' approaches to care and treatment of children with cancer when standard therapy has failed [J].

Bluebond-Langner, Myra ;

Belasco, Jean Bello ;

Goldman, Ann ;

Belasco, Carmen .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (17) :2414-2419

[5] PERCEPTIONS OF CANCER-PATIENTS AND THEIR PHYSICIANS INVOLVED IN PHASE-I TRIALS [J].

DAUGHERTY, C ;

RATAIN, MJ ;

GROCHOWSKI, E ;

STOCKING, C ;

KODISH, E ;

MICK, R ;

SIEGLER, M .

JOURNAL OF CLINICAL ONCOLOGY, 1995, 13 (05) :1062-1072

[6] Clinical Trial Participation as Part of End-of-Life Cancer Care: Associations With Medical Care and Quality of Life Near Death [J].

Enzinger, Andrea C. ;

Zhang, Baohui ;

Weeks, Jane C. ;

Prigerson, Holly G. .

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 2014, 47 (06) :1078-1090

[7] Do Phase 1 Patients Have Greater Needs for Palliative Care Compared With Other Cancer Patients? [J].

Finlay, Esme ;

Lu, Hien L. ;

Henderson, Hope ;

O'Dwyer, Peter J. ;

Casarett, David J. .

CANCER, 2009, 115 (02) :446-453

[8] Improved Quality of Life at End of Life Related to Home-Based Palliative Care in Children with Cancer [J].

Friedrichsdorf, Stefan J. ;

Postier, Andrea ;

Dreyfus, Jill ;

Osenga, Kaci ;

Sencer, Susan ;

Wolfe, Joanne .

JOURNAL OF PALLIATIVE MEDICINE, 2015, 18 (02) :143-150

[9] Risks and benefits of phase 1 oncology trials, 1991 through 2002 [J].

Horstmann, E ;

McCabe, MS ;

Grochow, L ;

Yamamoto, S ;

Rubinstein, L ;

Budd, T ;

Shoemaker, D ;

Emanuel, EJ ;

Grady, C .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (09) :895-904

[10] Differences in end-of-life communication for children with advanced cancer who were referred to a palliative care team [J].

Kassam, Alisha ;

Skiadaresis, Julia ;

Alexander, Sarah ;

Wolfe, Joanne .

PEDIATRIC BLOOD & CANCER, 2015, 62 (08) :1409-1413

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