Pre-treatment haemoglobin concentration is a prognostic factor in patients with early-stage breast cancer

被引：8

作者：

Kandemir, EG ^{[1
]}

Mayadagli, A ^{[1
]}

Turken, O ^{[1
]}

Yaylaci, M ^{[1
]}

Ozturk, A ^{[1
]}

机构：

[1] GATA Haydarpasa Training Hosp, Dept Med Oncol, Istanbul, Turkey

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2005年 / 33卷 / 03期

关键词：

breast cancer; anaemia; haemoglobin; concentration; prognostic factors;

D O I：

10.1177/147323000503300307

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We investigated the prevalence of anaemia (haemoglobin concentration < 12 g/dl) in 336 women with early-stage breast cancer and its association with other known prognostic factors. The median follow-up period was 60.5 months (range 9 123 months). Seventy-nine women (23.5%) had a low pre-treatment haemoglobin concentration, but anaemia was not correlated with age, tumour size, nodal status, histological grade or hormone receptor status. Univariate analysis revealed that disease-free survival and overall survival were shorter in patients with anaemia at the time of diagnosis than in patients with normal haemoglobin concentrations. Anaemia remained a significant prognostic factor for disease-free survival and overall survival in the multivariate analysis (relative risk, 1.884 and 1.785, respectively). These results suggest that pre-treatment haemoglobin concentration is an independent prognostic factor in patients with early-stage breast cancer.

引用

页码：319 / 328

页数：10

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