An electrochemical approach for detection of DNA methylation and assay of the methyltransferase activity

被引：95

作者：

Liu, Shuna ^{[1
]}

Wu, Ping ^{[1
]}

Li, Wen ^{[1
]}

Zhang, Hui ^{[1
]}

Cai, Chenxin ^{[1
]}

机构：

[1] Nanjing Normal Univ, Jiangsu Key Lab Power Batteries, Jiangsu Key Lab Biofunct Mat, Lab Electrochem,Coll Chem & Mat Sci, Nanjing 210097, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 10期

基金：

中国国家自然科学基金;

关键词：

COLORIMETRIC ASSAY; HYPERMETHYLATION; INHIBITORS; CYTOSINE;

D O I：

10.1039/c0cc05153e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This work develops an electrochemical approach for rapid detection of the genomic DNA methylation level, assay of methyltransferase activity, and evaluation and screening of the inhibitors of methyltransferase. This method may be a help for the discovery of anticancer drugs.

引用

收藏

页码：2844 / 2846

页数：3

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