Regulation of Inflammatory Cytokine Storms by Mesenchymal Stem Cells

被引：45

作者：

Wang, Lu ^{[1
,2
]}

Li, Yun ^{[1
,2
]}

Xu, Moyan ^{[3
]}

Deng, Zihui ^{[4
]}

Zhao, Yan ^{[2
]}

Yang, Mengmeng ^{[2
]}

Liu, Yuyan ^{[1
,2
]}

Yuan, Rui ^{[1
,2
]}

Sun, Yan ^{[5
]}

Zhang, Hao ^{[6
]}

Wang, Heming ^{[7
]}

Qian, Zhirong ^{[7
]}

Kang, Hongjun ^{[1
,2
]}

机构：

[1] Med Sch Chinese PLA, Beijing, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Crit Care Med, Beijing, Peoples R China

[3] Chinese Peoples Liberat Army Gen Hosp, Hlth Care Off, Beijing, Peoples R China

[4] Chinese Peoples Liberat Army Gen Hosp, Grad Sch, Dept Basic Med, Beijing, Peoples R China

[5] Capital Med Univ, Sch Publ Hlth, Beijing, Peoples R China

[6] Guangdong Univ Technol, Inst Biomed & Pharmaceut Sci, Guangzhou, Peoples R China

[7] Sun Yat Sen Univ, Affiliated Hosp 7, Sci Res Ctr, Shenzhen, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

关键词：

mesenchymal stem cells; cytokine storm syndrome; COVID-19; immune system; sepsis; STROMAL CELLS; THERAPEUTIC-EFFICACY; APOPTOSIS; COVID-19; MSCS; MACROPHAGES; ENHANCE; PROTECT;

D O I：

10.3389/fimmu.2021.726909

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mesenchymal stem cells (MSCs) have been widely used in preclinical and clinical trials for various diseases and have shown great potential in the treatment of sepsis and coronavirus disease (COVID-19). Inflammatory factors play vital roles in the pathogenesis of diseases. The interaction between inflammatory factors is extremely complex. Once the dynamics of inflammatory factors are unbalanced, inflammatory responses and cytokine storm syndrome develop, leading to disease exacerbation and even death. Stem cells have become ideal candidates for the treatment of such diseases due to their immunosuppressive and anti-inflammatory properties. However, the mechanisms by which stem cells affect inflammation and immune regulation are still unclear. This article discusses the therapeutic mechanism and potential value of MSCs in the treatment of sepsis and the novel COVID-19, outlines how MSCs mediate innate and acquired immunity at both the cellular and molecular levels, and described the anti-inflammatory mechanisms and related molecular pathways. Finally, we review the safety and efficacy of stem cell therapy in these two diseases at the preclinical and clinical levels.

引用

页数：14

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