Deprotonation-electrophile trapping of terminal epoxides

被引：18
作者：
Hodgson, DM
Kirton, EHM
Miles, SM
Norsikian, SLM
Reynolds, NJ
Coote, SJ
机构：
[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
[2] GlaxoSmithKline, Med Res Ctr, Stevenage SG1 2NY, Herts, England
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2005年 / 3卷 / 10期
关键词：
D O I：
10.1039/b502888d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Organolithium-induced deprotonation of terminal epoxides in the presence of appropriate diamine ligands allows trapping with a range of electrophiles, yielding functionalised di- and tri-substituted epoxides in good yields and with control of stereochemistry at the epoxide.
引用
收藏
页码：1893 / 1904
页数：12
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