Association of apolipoprotein E polymorphism to clinical heterogeneity of multiple sclerosis

被引：36
作者：
Ballerini, C
Campani, D
Rambolà, G
Gran, B
Nacmias, B
Amato, MP
Siracusa, G
Bartolozzi, L
Sorbi, S
Massacesi, L
机构：
[1] Univ Florence, Dept Neurol & Psychiat Sci, I-50134 Florence, Italy
[2] Careggi Univ Hosp, Serv Immunogenet, I-50134 Florence, Italy
来源：
NEUROSCIENCE LETTERS | 2000年 / 296卷 / 2-3期
关键词：
apolipoprotein E; multiple sclerosis; disease heterogeneity;
D O I：
10.1016/S0304-3940(00)01646-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this study we investigated the distribution of apolipoprotein E (APO E) genotypes in sporadic multiple sclerosis (MS) cases and in normal controls. Later onset of chronic progressive MS was observed in patients carrying the epsilon2 allele, whereas APO E alleles were found at similar frequency in MS and in the control population. These findings indicate that clinical heterogeneity, but probably not susceptibility to the disease, is associated to APO E genotypes. (C) 2000 Published by Elsevier Science Ireland Ltd.
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收藏
页码：174 / 176
页数：3
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