Impact of a Multidisciplinary Bundle on Time to Antibiotic Administration in Septic SICU Patients

被引:9
作者
Almalki, Ohoud [1 ]
Levine, Alexander R. [2 ]
Turner, Elizabeth [3 ]
Newman, Kelly [1 ]
DeMoya, Marc [3 ]
Lee, Jarone [4 ]
Bittner, Edward A. [5 ]
Lin, Hsin [1 ]
机构
[1] Massachusetts Gen Hosp, Dept Pharm, 55 Fruit St, Boston, MA 02114 USA
[2] Univ St Joseph, Dept Pharm Practice & Adm, Sch Pharm, Hartford, CT USA
[3] Massachusetts Gen Hosp, Div Trauma Emergency Surg & Surg Crit Care, Boston, MA 02114 USA
[4] Massachusetts Gen Hosp, Dept Surg & Emergency Med, Boston, MA 02114 USA
[5] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA
关键词
sepsis; quality; multidisciplinary critical care; SEVERE SEPSIS; UNITED-STATES; SHOCK; MANAGEMENT; SURVIVAL; THERAPY;
D O I
10.1177/0885066616656344
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Purpose: The goal of this study was to investigate barriers to timely antibiotic administration in septic surgical intensive care unit (SICU) patients and examine the impact of a multidisciplinary bundle on the time from prescription to antibiotic administration. Methods: This was a pre- and postintervention study that consisted of 3 phases: (1) preintervention phase, retrospective evaluation of data, (2) intervention implementation, and (3) a postintervention phase. A nurse survey was conducted to identify barriers to rapid antibiotic administration during phase 1. Based on this survey, multidisciplinary interventions included adding antibiotics to the automatic dispensing cabinet, educating monthly staff, and providing an antibiotic dosing table to all prescribers, which is attached to the computer workstations. Our multidisciplinary team consisted of the ICU medical directors, nurse managers, nurses, a critical care fellow, and ICU pharmacists. Results: The percentage of antibiotics that were received within 60 minutes was 26.3% in the pregroup versus 84.0% in the postgroup (P < .001). The mean total prescriber to patient time was 110 minutes in the pregroup versus 58.4 minutes in the postgroup (P < .001). Conclusion: We achieved a higher rate of timely antibiotic administration among septic SICU patients by implementing process changes based on barriers identified by the nurses.
引用
收藏
页码:494 / 499
页数:6
相关论文
共 15 条
[1]   Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care [J].
Angus, DC ;
Linde-Zwirble, WT ;
Lidicker, J ;
Clermont, G ;
Carcillo, J ;
Pinsky, MR .
CRITICAL CARE MEDICINE, 2001, 29 (07) :1303-1310
[2]   Antimicrobial stewardship A review of prospective audit and feedback systems and an objective evaluation of outcomes [J].
Chung, Gladys W. ;
Wu, Jia En ;
Yeo, Chay Leng ;
Chan, Douglas ;
Hsu, Li Yang .
VIRULENCE, 2013, 4 (02) :151-157
[3]   Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012 [J].
Dellinger, R. Phillip ;
Levy, Mitchell M. ;
Rhodes, Andrew ;
Annane, Djillali ;
Gerlach, Herwig ;
Opal, Steven M. ;
Sevransky, Jonathan E. ;
Sprung, Charles L. ;
Douglas, Ivor S. ;
Jaeschke, Roman ;
Osborn, Tiffany M. ;
Nunnally, Mark E. ;
Townsend, Sean R. ;
Reinhart, Konrad ;
Kleinpell, Ruth M. ;
Angus, Derek C. ;
Deutschman, Clifford S. ;
Machado, Flavia R. ;
Rubenfeld, Gordon D. ;
Webb, Steven A. ;
Beale, Richard J. ;
Vincent, Jean-Louis ;
Moreno, Rui ;
Aitken, Leanne ;
Al Rahma, Hussain ;
Annane, Dijillali ;
Bernard, Gordon R. ;
Biban, Paolo ;
Bion, Julian F. ;
Calandra, Thierry ;
Carcillo, Joseph A. ;
Clemmer, Terry P. ;
Divatia, J. V. ;
Du, Bin ;
Fujishima, Seitaro ;
Gando, Satoshi ;
Goodyear-Bruch, Caryl ;
Guyatt, Gordon ;
Hazelzet, Jan A. ;
Hirasawa, Hiroyuki ;
Hollenberg, Steven M. ;
Jacobi, Judith ;
Jenkins, Ian ;
Jimenez, Edgar ;
Jones, Alan E. ;
Kacmarek, Robert M. ;
Kern, Winfried ;
Koh, Shin Ok ;
Kotani, Joji ;
Levy, Mitchell .
CRITICAL CARE MEDICINE, 2013, 41 (02) :580-637
[4]   Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003 [J].
Dombrovskiy, Viktor Y. ;
Martin, Andrew A. ;
Sunderram, Jagadeeshan ;
Paz, Harold L. .
CRITICAL CARE MEDICINE, 2007, 35 (05) :1244-1250
[5]   Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department [J].
Gaieski, David F. ;
Mikkelsen, Mark E. ;
Band, Roger A. ;
Pines, Jesse M. ;
Massone, Richard ;
Furia, Frances F. ;
Shofer, Frances S. ;
Goyal, Munish .
CRITICAL CARE MEDICINE, 2010, 38 (04) :1045-1053
[6]   IMPROVING DOOR-TO-ANTIBIOTIC TIME IN SEVERELY SEPTIC EMERGENCY DEPARTMENT PATIENTS [J].
Hitti, Eveline A. ;
Lewin, John J., III ;
Lopez, Jose ;
Hansen, Jonathan ;
Pipkin, Michael ;
Itani, Taha ;
Gurny, Paul .
JOURNAL OF EMERGENCY MEDICINE, 2012, 42 (04) :462-468
[7]   Likelihood of infection in patients with presumed sepsis at the time of intensive care unit admission: a cohort study [J].
Klouwenberg, Peter M. C. Klein ;
Cremer, Olaf L. ;
van Vught, Lonneke A. ;
Ong, David S. Y. ;
Frencken, Jos F. ;
Schultz, Marcus J. ;
Bonten, Marc J. ;
van der Poll, Tom .
CRITICAL CARE, 2015, 19
[8]   Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock [J].
Kumar, Arland ;
Roberts, Daniel ;
Wood, Kenneth E. ;
Light, Bruce ;
Parrillo, Joseph E. ;
Sharma, Satendra ;
Suppes, Robert ;
Feinstein, Daniel ;
Zanotti, Sergio ;
Taiberg, Leo ;
Gurka, David ;
Kumar, Aseem ;
Cheang, Mary .
CRITICAL CARE MEDICINE, 2006, 34 (06) :1589-1596
[9]  
Levy MM, 2015, CRIT CARE MED, V43, P3, DOI [10.1007/s00134-014-3496-0, 10.1097/CCM.0000000000000723]
[10]   Effect of adding piperacillin-tazobactam to automated dispensing cabinets on promptness of first-dose antibiotics in hospitalized patients [J].
Lo, Amy ;
Zhu, Juanqi Nikki ;
Richman, Mark ;
Joo, Julianne ;
Chan, Patrick .
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2014, 71 (19) :1662-1667