Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease

被引：91

作者：

Oliveira, Luis M. A. ^{[1
]}

Gasser, Thomas ^{[2
,3
]}

Edwards, Robert ^{[4
,5
]}

Zweckstetter, Markus ^{[6
,7
]}

Melki, Ronald ^{[8
]}

Stefanis, Leonidas ^{[9
,10
,11
]}

Lashuel, Hilal A. ^{[12
]}

Sulzer, David ^{[13
,14
]}

Vekrellis, Kostas ^{[9
]}

Halliday, Glenda M. ^{[15
,16
]}

Tomlinson, Julianna J. ^{[18
]}

Schlossmacher, Michael ^{[18
,19
]}

Jensen, Poul Henning ^{[20
]}

Schulze-Hentrich, Julia ^{[17
,21
]}

Riess, Olaf ^{[17
,21
]}

Hirst, Warren D. ^{[22
]}

El-Agnaf, Omar ^{[23
]}

Mollenhauer, Brit ^{[24
,25
]}

Lansbury, Peter ^{[26
]}

Outeiro, Tiago F. ^{[6
,27
,28
,29
]}

机构：

[1] Michael J Fox Fdn Parkinsons Res, New York, NY 10163 USA

[2] Univ Tubingen, Hertie Inst Clin Brain Res, Dept Neurodegenerat Dis, Tubingen, Germany

[3] German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany

[4] UCSF Sch Med, Dept Neurol, San Francisco, CA USA

[5] UCSF Sch Med, Dept Physiol, San Francisco, CA USA

[6] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

[7] Max Planck Inst Biophys Chem, Dept NMRbased Struct Biol, Gottingen, Germany

[8] CNRS, CEA & Lab Neurodegenerat Dis, MIRCen, Inst Francois Jacob, Fontenay Aux Roses, France

[9] Biomed Res Fdn Acad Athens, Athens, Greece

[10] Kapodistrian Univ Athens, Dept Neurol 1, Athens, Greece

[11] Kapodistrian Univ Athens, Med Sch Natl, Athens, Greece

[12] Ecole Polytech Fed Lausanne, Fac Life Sci, Brain Mind Inst, Laby Mol & Chem Biol Neurodegenerat, Lausanne, Switzerland

[13] Columbia Univ, Dept Psychiat Neurol Mol Pharmacol & Ther, New York, NY USA

[14] New York State Psychiat Inst & Hosp, Div Mol Therapeut, New York, NY USA

[15] Univ Sydney, Brain & Mind Ctr, Sch Med Sci, Sydney, NSW, Australia

[16] Univ Sydney, Fac Med & Hlth, Sch Med Sci, Sydney, NSW, Australia

[17] Ottawa Hosp, Neurosci Program, Ottawa, ON, Canada

[18] Univ Ottawa, Brain & Mind Res Inst, Ottawa, ON, Canada

[19] Ottawa Hosp, Div Neurol, Ottawa, ON, Canada

[20] Aarhus Univ, Dept Biomedicine & DANDRITE, Danish Res Inst Translat Neurosci, Aarhus, Denmark

[21] Univ Tubingen, Inst Med Genet & Appl Gen, Tubingen, Germany

[22] Neurodegenerat Dis Res Unit Biogen, Cambridge, MA USA

[23] Hamad Bin Khalifa Univ HBKU, Qatar Biomed Res Inst QBRI, Neurol Disorder Res Ctr, Doha, Qatar

[24] Univ Med Ctr Gottingen, Dept Neurol, Gottingen, Germany

[25] Paracelsus Elena Klinik, Kassel, Germany

[26] Lysosomal Therapeutics Inc, Cambridge, MA USA

[27] Univ Med Ctr Gottingen, Ctr Biostructural Imaging Neurodegenerat, Dept Expt Neurodegenerat, Gottingen, Germany

[28] Max Planck Inst Expt Med, Gottingen, Germany

[29] Newcastle Univ, Fac Med Sci, Translat & Clin Res Inst, Newcastle, NSW, Australia

来源：

NPJ PARKINSONS DISEASE | 2021年 / 7卷 / 01期

基金：

欧盟地平线“2020”; 英国医学研究理事会;

关键词：

RED-BLOOD-CELLS; MULTIPLE SYSTEM ATROPHY; GENOME-WIDE ASSOCIATION; LEWY BODY PATHOLOGY; A-BETA COMPONENT; AUTOSOMAL-DOMINANT; ALZHEIMERS-DISEASE; RAT MODEL; MONOCLONAL-ANTIBODIES; POTENTIAL BIOMARKER;

D O I：

10.1038/s41531-021-00203-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

With the advent of the genetic era in Parkinson's disease (PD) research in 1997, alpha-synuclein was identified as an important player in a complex neurodegenerative disease that affects >10 million people worldwide. PD has been estimated to have an economic impact of $51.9 billion in the US alone. Since the initial association with PD, hundreds of researchers have contributed to elucidating the functions of alpha-synuclein in normal and pathological states, and these remain critical areas for continued research. With this position paper the authors strive to achieve two goals: first, to succinctly summarize the critical features that define alpha-synuclein's varied roles, as they are known today; and second, to identify the most pressing knowledge gaps and delineate a multipronged strategy for future research with the goal of enabling therapies to stop or slow disease progression in PD.

引用

页数：23

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