Safety, efficacy and pharmacokinetics of nimotuzumab, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients with locally advanced or metastatic pancreatic cancer

被引:0
作者
Strumberg, D. [1 ]
Schultheis, B. [1 ]
Scheulen, M. E. [2 ]
Hilger, R. A. [2 ]
Krauss, J. [2 ]
Marschner, N. [3 ]
Lordick, F. [4 ]
Bach, F. [5 ]
Reuter, D. [5 ]
Edler, L. [6 ]
Mross, K. [7 ]
机构
[1] Univ Bochum, Dept Hematol & Med Oncol, Marienhosp Herne, D-44625 Herne, Germany
[2] Univ Hosp Essen, Dept Med Oncol, Essen, Germany
[3] Onkol Schwerpunktpraxis Freiburg, Freiburg, Germany
[4] Univ Hosp Munich, Klinikum Rechts Isar, Dept Hematol & Med Oncol, Munich, Germany
[5] Oncosci AG, Wedel, Germany
[6] German Canc Res Ctr, D-6900 Heidelberg, Germany
[7] Univ Freiburg, Tumor Biol Ctr, Freiburg, Germany
关键词
pancreatic cancer; nimotuzumab; EGFR antibody; clinical trial; advanced disease; CLINICAL BENEFIT; GEMCITABINE; MUTATIONS; SURVIVAL; TRIAL;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:473 / 475
页数:3
相关论文
共 8 条
[1]   Nimotuzumab: Evidence of clinical benefit without rash [J].
Allan, DGP .
ONCOLOGIST, 2005, 10 (09) :760-761
[2]   Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial [J].
Burris, HA ;
Moore, MJ ;
Andersen, J ;
Green, MR ;
Rothenberg, ML ;
Madiano, MR ;
Cripps, MC ;
Portenoy, RK ;
Storniolo, AM ;
Tarassoff, P ;
Nelson, R ;
Dorr, FA ;
Stephens, CD ;
VanHoff, DD .
JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (06) :2403-2413
[3]   Cancer statistics, 2008 [J].
Jemal, Ahmedin ;
Siegel, Rebecca ;
Ward, Elizabeth ;
Hao, Yongping ;
Xu, Jiaquan ;
Murray, Taylor ;
Thun, Michael J. .
CA-A CANCER JOURNAL FOR CLINICIANS, 2008, 58 (02) :71-96
[4]  
Lam C, 2009, FUTURE ONCOL, V5, P1349, DOI [10.2217/fon.09.119, 10.2217/FON.09.119]
[5]   Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplilications, and KRAS mutations on survival of pancreatic adenocarcinoma [J].
Lee, Jeeyun ;
Jang, Kee-Taek ;
Ki, Chang-Seok ;
Lim, Taekyu ;
Park, Young Suk ;
Lim, Ho Yeong ;
Choi, Dong-Wook ;
Kaing, Won Ki ;
Park, Keunchil ;
Park, Joon Oh .
CANCER, 2007, 109 (08) :1561-1569
[6]   Pancreatic cancer [J].
Li, DH ;
Xie, KP ;
Wolff, R ;
Abbruzzese, JL .
LANCET, 2004, 363 (9414) :1049-1057
[7]   Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib [J].
Lynch, TJ ;
Bell, DW ;
Sordella, R ;
Gurubhagavatula, S ;
Okimoto, RA ;
Brannigan, BW ;
Harris, PL ;
Haserlat, SM ;
Supko, JG ;
Haluska, FG ;
Louis, DN ;
Christiani, DC ;
Settleman, J ;
Haber, DA .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (21) :2129-2139
[8]   Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada clinical trials group [J].
Moore, Malcolm J. ;
Goldstein, David ;
Hamm, John ;
Figer, Arie ;
Hecht, Joel R. ;
Gallinger, Steven ;
Au, Heather J. ;
Murawa, Pawel ;
Walde, David ;
Wolff, Robert A. ;
Campos, Daniel ;
Lim, Robert ;
Ding, Keyue ;
Clark, Gary ;
Voskoglou-Nomikos, Theodora ;
Ptasynski, Mieke ;
Parulekar, Wendy .
JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (15) :1960-1966