New coumarin glycosides from the leaves of Diospyros crassiflora (Hiern)

被引：19
作者：
Akak, Carine Mvot [1 ,2 ]
Djama, Celine Mbazoa [2 ]
Nkengfack, Augustin Ephrem [2 ]
Tu, Peng-Fei [1 ]
Lei, Lian-Di [1 ]
机构：
[1] Peking Univ Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
[2] Univ Yaounde I, Fac Sci, Dept Organ Chem, Yaounde, Cameroon
来源：
FITOTERAPIA | 2010年 / 81卷 / 07期
关键词：
Diospyros crassiflora; Ebenaceae; Coumarin glycosides; Diosfeboside A; Diosfeboside B; Cytotoxic activity; 4-HYDROXYCOUMARIN; NAPHTHOQUINONE; BIOSYNTHESIS; DERIVATIVES; INHIBITORS; BETALAINS;
D O I：
10.1016/j.fitote.2010.05.011
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new 5-methylcoumarin glycosides named diosfeboside A (1) and B (2) and five known compounds namely kaempferol 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranoside (3), ursolic acid (4), betulinic acid (5), stigmasterol (6) and stigmasterol 3-O-beta-D-glucopyranoside (7) were isolated from the leaves of Diospyros crassiflora (Hiern). Their structures were established through interpretation of 1 and 2D NMR, mass spectra analysis and comparison with reported data. In vitro cytotoxic activity of the new compounds against human carcinoma cell lines (HL-60, Bel-7402, BGC-823, and KB) was evaluated and no cytotoxicity was observed for each of them. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：873 / 877
页数：5
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