Cell Resistant Peptidomimetic Poly (2-ethyl-2-oxazoline) Coatings Developed by Low Pressure Inductively Excited Pulsed Plasma Polymerization for Biomedical Purpose

被引：21

作者：

Bhatt, Sudhir ^{[1
,2
]}

Pulpytel, Jerome ^{[1
,2
]}

Mirshahi, Massoud ^{[3
]}

Arefi-Khonsari, Farzaneh ^{[1
,2
]}

机构：

[1] Sorbonne Univ, Univ Paris 06, UMR8235, LISE, Paris, France

[2] CNRS, UMR8235, LISE, Paris, France

[3] Fac Med Paris VI, Ctr Rech Cordeliers, UMRS 872, Paris, France

来源：

PLASMA PROCESSES AND POLYMERS | 2015年 / 12卷 / 06期

关键词：

alternative of PEG; biomedical applications; cell resistance coatings; nano thick peptidomimetic coatings; plasma polymerization; poly (2-ethyl-2oxazoline); THIN-FILMS; ADSORPTION; PROTEINS; COPOLYMERIZATION; ADHESION; GLYCOL);

D O I：

10.1002/ppap.201400169

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

In the present work, for the first time, nano-thick peptidomimetic coatings were developed using a LP inductively excited pulsed plasma polymerization of 2-ethyl-2-oxazoline (ppEtOz) to control the cell-surface interactions for biological applications. The different ppEtOz coated surfaces were investigated by FTIR-ATR, XPS, Ellipsometric, and WCA analysis. Using Gaussian deconvolution method for IR spectra, we compared the modifications obtained in the chemical compositions for ppEtOz coated samples obtained under different plasma parameters. It was found that the amide I/amide II ratios decreased as the effective plasma power increased, which in turn decreased the surface hydrophilicity for ppEtOz coatings. Cell repellent properties of the ppEtOz coatings deposited at P-eff=1W and 2.5W were achieved.

引用

页码：519 / 532

页数：14

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