Renal cell carcinoma metastatic to the testis and its adnexa: A report of five cases including three that accounted for the initial clinical presentation

被引:29
作者
Datta, MW
Ulbright, TM
Young, RH
机构
[1] Med Coll Wisconsin, Dept Pathol, Milwaukee, WI 53226 USA
[2] Froedtert Mem Lutheran Hosp, Dept Pathol, Milwaukee, WI USA
[3] Indiana Univ, Sch Med, Dept Pathol, Indianapolis, IN 46202 USA
[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, James Homer Wright Pathol Labs, Boston, MA 02114 USA
关键词
testis; metastasis; renal cell carcinoma;
D O I
10.1177/106689690100900108
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Five cases of renal cell carcinoma metastatic to the testis or its adnexa are described, including 3 that represented the initial presentation and mimicked primary testicular neoplasms. The patients ranged from 46 to 85 years of age. Three presented with self-identified testicular masses. One patient was investigated because of fever of unknown origin and was found to have a left rib metastasis. Further work-up led to the discovery of a testicular mass. The final patient had a tumor of the spermatic cord that was examined without knowledge that he had a Drier renal neoplasm. All the tumors were unilateral. They ranged from 1.8 to 5.0 cm; multiple rumor nodules were present in one of them but the others were discrete solitary masses. Four tumors were yellow/yellow-tan, and one was gray. On microscopic examination all the tumors were of the clear cell type. Patterns included solid sheets, acini, cysts, alveoli, and trabeculae. Two had prominent vascular invasion. Diagnoses initially entertained in these cases included Sertoli cell tumor, Sertoli-Leydig cell tumor, and clear cell cystadenoma of the epididymis. In 3 cases a kidney tumor was discovered 2 to 4 weeks after the diagnosis of renal cell carcinoma metastatic to the testis was rendered. On follow-up two patients died of rumor, and two were alive (5 months and 1 year) after orchiectomy. The diagnosis of renal cell carcinoma metastatic to the testis should be considered in evaluating a clear cell tumor of the testis, particularly in an older male or if the appearance suggests a Sertoli cell tumor. The differences in survival between metastatic renal cell carcinoma and sex cord-stromal tumors indicate the importance of considering the former in the differential.
引用
收藏
页码:49 / 56
页数:8
相关论文
共 50 条
[1]   SOLITARY TESTICULAR METASTASIS SIMULATING PRIMARY TUMOR AND ANTEDATING CLINICAL HYPERNEPHROMA OF THE KIDNEY - REPORT OF A CASE [J].
BANDLER, CG ;
ROEN, PR .
JOURNAL OF UROLOGY, 1946, 55 (06) :663-669
[2]   RENAL-CELL CARCINOMA INVOLVING PENIS AND TESTIS - UNUSUAL INITIAL PRESENTATIONS OF METASTATIC DISEASE [J].
DANIELS, GF ;
SCHAEFFER, AJ .
UROLOGY, 1991, 37 (04) :369-373
[3]   Malignant melanoma metastatic to the testis: A report of three cases with clinically significant manifestations [J].
Datta, MW ;
Young, RH .
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2000, 8 (01) :49-57
[4]  
de Riese W, 1986, Int Urol Nephrol, V18, P449
[5]  
DEVILLALONGA MB, 1994, ARCH ESP UROL, V47, P281
[6]  
DIECKMANN KP, 1988, EUR UROL, V15, P297
[7]  
ELSON PJ, 1988, CANCER RES, V48, P7310
[8]  
GRIGNON DJ, 1986, CAN J SURG, V29, P359
[9]   METASTATIC TUMORS TO TESTICLES - ROUTES OF METASTASIS [J].
HANASH, KA ;
CARNEY, JA ;
KELALIS, PP .
JOURNAL OF UROLOGY, 1969, 102 (04) :465-&
[10]  
HAUPT HM, 1984, CANCER, V54, P709, DOI 10.1002/1097-0142(1984)54:4<709::AID-CNCR2820540419>3.0.CO