Next-generation sequencing and clinical histocompatibility testing

被引：10

作者：

Cornaby, Caleb ^{[1
]}

Schmitz, John L. ^{[1
,2
]}

Weimer, Eric T. ^{[1
,2
]}

机构：

[1] UNC Hlth, McLendon Clin Labs, Chapel Hill, NC USA

[2] Univ N Carolina, Dept Pathol & Lab Med, Sch Med, Chapel Hill, NC 27515 USA

来源：

HUMAN IMMUNOLOGY | 2021年 / 82卷 / 11期

关键词：

HLA; NGS; Next-generation sequencing; Histocompatibility; Transplant; HUMAN-LEUKOCYTE ANTIGEN; HEMATOPOIETIC-CELL TRANSPLANTATION; POLYMERASE-CHAIN-REACTION; PRIMERS PCR-SSP; HIGH-RESOLUTION; HLA-DR; DISEASE ASSOCIATION; DNA; AMPLIFICATION; EXPRESSION;

D O I：

10.1016/j.humimm.2021.08.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Histocompatibility testing is essential for donor identification and risk assessment in solid organ and hematopoietic stem cell transplant. Additionally, it is useful for identifying donor specific alleles for monitoring donor specific antibodies in post-transplant patients. Next-generation sequence (NGS) based human leukocyte antigen (HLA) typing has improved many aspects of histocompatibility testing in hematopoietic stem cell and solid organ transplant. HLA disease association testing and research has also benefited from the advent of NGS technologies. In this review we discuss the current impact and future applications of NGS typing on clinical histocompatibility testing for transplant and non-transplant purposes. (c) 2021 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：829 / 837

页数：9

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