Influence of different types of cyclodextrins on the racemization of scopolamine-N-butylbromide

被引：14

作者：

Bunke, A ^{[1
]}

Jira, T ^{[1
]}

Beyrich, T ^{[1
]}

机构：

[1] UNIV GREIFSWALD,DEPT PHARM,INST DRUG CONTROL,D-17487 GREIFSWALD,GERMANY

来源：

JOURNAL OF CHROMATOGRAPHY A | 1996年 / 728卷 / 1-2期

关键词：

racemization; mobile-phase composition; enantiomer separation; cyclodextrins; scopolamine-N-butylbromide; tropic acid;

D O I：

10.1016/0021-9673(95)01060-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The influence of cyclodextrins (CDs) on the racemization and hydrolysis of scopolamine-N-butylbromide was determined kinetically. alpha-CD and gamma-CD enhance the racemization rate of the substance. beta-CD shows no effect and DM-beta-CD (dimethyl-beta-CD) causes inhibition of racemization. The hydrolysis of the substance was retarded by beta-, gamma- and DM-beta-CD. In the presence of alpha-CD no change in hydrolysis rate was observed.

引用

页码：441 / 445

页数：5

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