Role of biomarkers in risk stratification of acute coronary syndrome

被引：0

作者：

Nagesh, C. M. ^{[1
]}

Roy, Ambuj ^{[1
]}

机构：

[1] All India Inst Med Sci, Dept Cardiol, Ctr Cardiothorac, New Delhi 110029, India

来源：

INDIAN JOURNAL OF MEDICAL RESEARCH | 2010年 / 132卷 / 05期

关键词：

Acute coronary syndrome; brain natriuretic peptide; cardiac biomarkers; CRP; cystatin C; troponin; C-REACTIVE PROTEIN; CARDIAC TROPONIN-I; SOLUBLE CD40 LIGAND; LONG-TERM MORTALITY; MYOCARDIAL-INFARCTION; NATRIURETIC PEPTIDE; PROGNOSTIC VALUE; CYSTATIN-C; CREATINE-KINASE; UNSTABLE ANGINA;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Diagnosis of acute coronary syndrome (ACS) encompasses a wide spectrum of myocardial ischaemia varying from assuredly benign to potentially fatal. Cardiac biomarkers have had a major impact on the management of this disease and are now the cornerstone in its diagnosis and prognosis. In this review we discuss both the established and the newer emerging biomarkers in ACS and their role in highlighting not only myocardial necrosis but also different facets of the pathophysiology of ACS. The future of cardiac biomarker testing may be in multimarker testing to better characterize each patient of ACS and thus tailor both short-term and long-term therapy accordingly. This novel concept, however, needs to be tested in clinical trials for its incremental value and cost-effectiveness.

引用

页码：627 / 633

页数：7

共 48 条

[1] Myocardial infarction redefined -: A consensus Document of the Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction [J].

Alpert, JS ;

Antman, E ;

Apple, F ;

Armstrong, PW ;

Bassand, JP ;

de Luna, AB ;

Beller, G ;

Breithardt, G ;

Chaitman, BR ;

Clemmensen, P ;

Falk, E ;

Fishbein, MC ;

Galvani, M ;

Garson, A ;

Grines, C ;

Hamm, C ;

Jaffe, A ;

Katus, H ;

Kjekshus, J ;

Klein, W ;

Klootwijk, P ;

Lenfant, C ;

Levy, D ;

Levy, RI ;

Luepker, R ;

Marcus, F ;

Näslund, U ;

Ohman, M ;

Pahlm, O ;

Poole-Wilson, P ;

Popp, R ;

Alto, P ;

Pyörälä, K ;

Ravkilde, J ;

Rehnquist, N ;

Roberts, W ;

Roberts, R ;

Roelandt, J ;

Rydén, L ;

Sans, S ;

Simoons, ML ;

Thygesen, K ;

Tunstall-Pedoe, H ;

Underwood, R ;

Uretsky, BF ;

Van de Werf, F ;

Voipio-Pulkki, LM ;

Wagner, G ;

Wallentin, L ;

Wijns, W .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (03) :959-969

[2] Platelet-derived CD40L -: The switch-hitting player of cardiovascular disease [J].

André, P ;

Nannizzi-Alaimo, L ;

Prasad, SK ;

Phillips, DR .

CIRCULATION, 2002, 106 (08) :896-899

[3] Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes [J].

Antman, EM ;

Tanasijevic, MJ ;

Thompson, B ;

Schactman, M ;

McCabe, CH ;

Cannon, CP ;

Fischer, GA ;

Fung, AY ;

Thompson, C ;

Wybenga, D ;

Braunwald, E .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (18) :1342-1349

[4] Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome [J].

Apple, FS ;

Wu, AHB ;

Mair, J ;

Ravkilde, J ;

Panteghini, M ;

Tate, J ;

Pagani, F ;

Christenson, RH ;

Mockel, M ;

Danne, O ;

Jaffe, AS .

CLINICAL CHEMISTRY, 2005, 51 (05) :810-824

[5] Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction [J].

Askari, AT ;

Brennan, ML ;

Zhou, XR ;

Drinko, J ;

Morehead, A ;

Thomas, JD ;

Topol, EJ ;

Hazen, SL ;

Penn, MS .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (05) :615-624

[6] Ischemia modified albumin measured by the albumin cobalt binding test: A clinical and analytical review [J].

Aslan, D ;

Apple, FS .

LABORATORY MEDICINE, 2004, 35 (01) :44-47

[7] Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction [J].

Aviles, RJ ;

Askari, AT ;

Lindahl, B ;

Wallentin, L ;

Jia, G ;

Ohman, EM ;

Mahaffey, KW ;

Newby, LK ;

Califf, RM ;

Simoons, ML ;

Topol, EJ ;

Lauer, MS ;

Berger, P .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (26) :2047-2052

[8] Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes [J].

Baldus, S ;

Heeschen, C ;

Meinertz, T ;

Zeiher, AM ;

Eiserich, JP ;

Münzel, T ;

Simoons, ML ;

Hamm, CW .

CIRCULATION, 2003, 108 (12) :1440-1445

[9] Pregnancy-associated plasma protein a as a marker of acute coronary syndromes [J].

Bayes-Genis, A ;

Conover, CA ;

Overgaard, MT ;

Bailey, KR ;

Christiansen, M ;

Holmes, DR ;

Virmani, R ;

Oxvig, C ;

Schwartz, RS .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (14) :1022-1029

[10]

Bogaty P, 2008, J AM COLL CARDIOL, V51, pA219

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