A single-cell survey of the human first-trimester placenta and decidua

被引：266
|
作者：
Suryawanshi, Hemant [1 ,2 ]
Morozov, Pavel [1 ,2 ]
Straus, Alexander [3 ]
Sahasrabudhe, Nicole [4 ]
Max, Klaas E. A. [1 ,2 ]
Garzia, Aitor [1 ,2 ]
Kustagi, Manjunath [1 ,2 ]
Tuschl, Thomas [1 ,2 ]
Williams, Zev [3 ]
机构：
[1] Rockefeller Univ, Howard Hughes Med Inst, 1230 York Ave,Box 186, New York, NY 10065 USA
[2] Rockefeller Univ, Lab RNA Mol Biol, 1230 York Ave,Box 186, New York, NY 10065 USA
[3] Columbia Univ, Dept Obstet & Gynecol, Med Ctr, 630 W 168th St, New York, NY 10032 USA
[4] Albert Einstein Coll Med, Dept Obstet & Gynecol, Bronx, NY 10461 USA
来源：
SCIENCE ADVANCES | 2018年 / 4卷 / 10期
关键词：
LARGE GENE LISTS; EXPRESSION; PREECLAMPSIA; PREGNANCY; GROWTH; DECIDUALIZATION; TRANSCRIPTOMICS; TROPHOBLAST; MECHANISMS; REVEALS;
D O I：
10.1126/sciadv.aau4788
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The placenta and decidua interact dynamically to enable embryonic and fetal development. Here, we report single-cell RNA sequencing of 14,341 and 6754 cells from first-trimester human placental villous and decidual tissues, respectively. Bioinformatic analysis identified major cell types, many known and some subtypes previously unknown in placental villi and decidual context. Further detailed analysis revealed proliferating subpopulations, enrichment of cell type-specific transcription factors, and putative intercellular communication in the fetomaternal microenvironment. This study provides a blueprint to further the understanding of the roles of these cells in the placenta and decidua for maintenance of early gestation as well as pathogenesis in pregnancy-related disorders.
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收藏
页数：12
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