Early neonatal brain injury in histologic chorioamnionitis

被引:118
作者
De Felice, C
Toti, P
Laurini, RN
Stumpo, M
Picciolini, E
Todros, T
Tanganelli, P
Buonocore, G
Bracci, R
机构
[1] Univ Siena, Dept Prevent Pediat & Neonatol, I-53100 Siena, Italy
[2] Univ Siena, Inst Pathol, I-53100 Siena, Italy
[3] Univ Siena, Dept Obstet & Gynecol, I-53100 Siena, Italy
[4] Univ Turin, Div Fetomaternal Med, Turin, Italy
[5] Univ Lausanne, Div Dev Pathol, Lausanne, Switzerland
关键词
D O I
10.1067/mpd.2001.109605
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The relation between clinical or histologic chorioamnionitis and early neonatal adverse neurologic outcome was investigated (n = 483). Histologic, but not clinical, evidence of chorioamnionitis was found to be a significant predictor of per;ventricular echodensity (odds ratio, 2.4; 95% CI, 1.8-3.2), echolucency (3.3; 1.9-5.6), ventriculomegaly (2.7; 1.8-4.2), intraventricular hemorrhage greater than or equal to3 (3.5; 2.4-5.2), and seizures (2.3; 1.4-3.7).
引用
收藏
页码:101 / 104
页数:4
相关论文
共 19 条
[1]   Role of the placenta in perinatal pathology (revisited) [J].
Altshuler, G .
PEDIATRIC PATHOLOGY & LABORATORY MEDICINE, 1996, 16 (02) :207-233
[2]   Placental histology and clinical characteristics of patients with preterm premature rupture of membranes [J].
Arias, F ;
Victoria, A ;
Cho, K ;
Kraus, F .
OBSTETRICS AND GYNECOLOGY, 1997, 89 (02) :265-271
[3]   Amniotic fluid concentrations of Interleukin-1β, Interleukin-6 and TNF-α in chorioamnionitis before 32 weeks of gestation:: histological associations and neonatal outcome [J].
Baud, O ;
Emilie, D ;
Pelletier, E ;
Lacaze-Masmonteil, T ;
Zupan, V ;
Fernandez, H ;
Dehan, M ;
Frydman, R ;
Ville, Y .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1999, 106 (01) :72-77
[4]   Intrauterine infection, cytokines, and brain damage in the preterm newborn [J].
Dammann, O ;
Leviton, A .
PEDIATRIC RESEARCH, 1997, 42 (01) :1-8
[5]   Small thymus in very low birth weight infants born to mothers with subclinical chorioamnionitis [J].
De Felice, C ;
Toti, P ;
Santopietro, R ;
Stumpo, M ;
Pecciarini, L ;
Bagnoli, F .
JOURNAL OF PEDIATRICS, 1999, 135 (03) :384-386
[6]   THE SPECTRUM OF LEUKOMALACIA USING CRANIAL ULTRASOUND [J].
DEVRIES, LS ;
EKEN, P ;
DUBOWITZ, LMS .
BEHAVIOURAL BRAIN RESEARCH, 1992, 49 (01) :1-6
[7]   The fetal inflammatory response syndrome [J].
Gomez, R ;
Romero, R ;
Ghezzi, F ;
Yoon, BH ;
Mazor, M ;
Berry, SM .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1998, 179 (01) :194-202
[8]   Maternal infection and cerebral palsy in infants of normal birth weight [J].
Grether, JK ;
Nelson, KB .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (03) :207-211
[9]  
HOBEL C, 1992, PERINATOLOGY, V26, P111
[10]  
Inder T E, 2000, Semin Neonatol, V5, P3, DOI 10.1053/siny.1999.0112