Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos

被引:29
|
作者
Kumar, Vijay [1 ]
Goutam, Ravi Shankar [1 ]
Park, Soochul [2 ]
Lee, Unjoo [3 ]
Kim, Jaebong [1 ]
机构
[1] Hallym Univ, Coll Med, Inst Cell Differentiat & Aging, Dept Biochem, Chunchon 24252, South Korea
[2] Sookmyung Womens Univ, Dept Biol Sci, Seoul 04310, South Korea
[3] Hallym Univ, Dept Elect Engn, Chunchon 24252, South Korea
基金
新加坡国家研究基金会;
关键词
FGF; FGFR; embryonic development; germ layer formation; transcription regulation; embryonic patterning; FIBROBLAST-GROWTH-FACTOR; LEFT-RIGHT AXIS; FACTOR RECEPTOR FAMILY; NODAL-RELATED SIGNALS; LEFT-RIGHT ASYMMETRY; NEURAL INDUCTION; MESODERM INDUCTION; DEFINITIVE ENDODERM; HOMOLOGOUS FACTORS; MOLECULAR-CLONING;
D O I
10.3390/cells10082148
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Fibroblast growth factors (FGFs) comprise a large family of growth factors, regulating diverse biological processes including cell proliferation, migration, and differentiation. Each FGF binds to a set of FGF receptors to initiate certain intracellular signaling molecules. Accumulated evidence suggests that in early development and adult state of vertebrates, FGFs also play exclusive and context dependent roles. Although FGFs have been the focus of research for therapeutic approaches in cancer, cardiovascular disease, and metabolic syndrome, in this review, we mainly focused on their role in germ layer specification and axis patterning during early vertebrate embryogenesis. We discussed the functional roles of FGFs and their interacting partners as part of the gene regulatory network for germ layer specification, dorsal-ventral (DV), and anterior-posterior (AP) patterning. Finally, we briefly reviewed the regulatory molecules and pharmacological agents discovered that may allow modulation of FGF signaling in research.
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收藏
页数:21
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