Targeting Antibiotic Resistance

被引：389

作者：

Chellat, Mathieu F. ^{[1
]}

Raguz, Luka ^{[1
]}

Riedl, Rainer ^{[1
]}

机构：

[1] Zurich Univ Appl Sci ZHAW, Ctr Organ & Med Chem, Inst Chem & Biotechnol, Einsiedlerstr 31, CH-8820 Wadenswil, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 23期

关键词：

antibiotics; antibiotic resistance; drug design; medicinal chemistry; structure-activity relationships; IN-VITRO ACTIVITY; PEPTIDYL-TRANSFERASE CENTER; BETA-LACTAMASE INHIBITOR; SIDEROPHORE-CONJUGATED MONOCARBAMS; STRUCTURAL BASIS; CRYSTAL-STRUCTURE; STAPHYLOCOCCUS-AUREUS; PROTEIN-SYNTHESIS; TRANSFER-RNA; 4-AMINOTHIAZOLYL ANALOGS;

D O I：

10.1002/anie.201506818

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Finding strategies against the development of antibiotic resistance is a major global challenge for the life sciences community and for public health. The past decades have seen a dramatic worldwide increase in human-pathogenic bacteria that are resistant to one or multiple antibiotics. More and more infections caused by resistant microorganisms fail to respond to conventional treatment, and in some cases, even last-resort antibiotics have lost their power. In addition, industry pipelines for the development of novel antibiotics have run dry over the past decades. A recent world health day by the World Health Organization titled "Combat drug resistance: no action today means no cure tomorrow" triggered an increase in research activity, and several promising strategies have been developed to restore treatment options against infections by resistant bacterial pathogens.

引用

页码：6600 / 6626

页数：27

共 204 条

[1] NEW ANTIBIOTIC THAT ACTS SPECIFICALLY ON THE GTP-BOUND FORM OF ELONGATION FACTOR-TU [J].