Projections and neurochemistry of interneurones in the myenteric plexus of the guinea-pig gastric corpus

被引：14
作者：
Reiche, D [1 ]
Michel, K [1 ]
Pfannkuche, H [1 ]
Schemann, M [1 ]
机构：
[1] Sch Vet Med, Dept Physiol, D-30173 Hannover, Germany
来源：
NEUROSCIENCE LETTERS | 2000年 / 295卷 / 03期
关键词：
enteric nervous system; gastric myenteric plexus; calbindin; interneurones; neurochemical coding;
D O I：
10.1016/S0304-3940(00)01617-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recently, motor neurones of the myenteric plexus innervating the muscle layers or the mucosa have been identified in the guinea-pig stomach. We applied the neuronal tracer Dil (1,1'-didodecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorat) onto myenteric ganglia in order to identify populations of interneurones in the myenteric plexus of the guinea-pig stomach. The tracing was combined with the immunohistochemical detection of calbindinD28k (CALB), choline acetyltransferase (ChAT), neuropeptide Y (NPY) and 5-hydroxytryptamine (serotonin) (5-HT) and the results were compared to the neurochemical coding of target specific motor neurones. Long projecting (similar to5.4 mm) ChAT/CALB/+/-5-HT-, nitric oxide synthase (NOS)/CALB- and short projecting (similar to1.1 mm) ChAT/NPY-neurones were identified as descending interneurones. CALB positive ascending interneurones contained ChAT but rarely 5-HT (code: ChAT/CALB). This study identified ascending and descending interneurones in the gastric myenteric plexus and revealed the neurochemical coding of some of the interneurone populations. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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页码：109 / 112
页数：4
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