One-Pot Three-Component Synthesis of 4(3H)-Quinazolinones from Benzyl Halides, Isatoic Anhydride, and Primary Amines

被引：50
作者：
Adib, Mehdi [1 ]
Sheikhi, Ehsan [1 ]
Bijanzadeh, Hamid Reza [2 ]
机构：
[1] Univ Tehran, Univ Coll Sci, Sch Chem, Tehran, Iran
[2] Tarbiat Modares Univ, Dept Chem, Tehran, Iran
来源：
SYNLETT | 2012年 / 23卷 / 01期
关键词：
benzyl halides; Kornblum oxidation; isatoic anhydride; amines; 4(3H)-quinazolinones; multicomponent reactions; MULTICOMPONENT REACTIONS; FACILE SYNTHESIS; MICROWAVE IRRADIATION; ASYMMETRIC-SYNTHESIS; SELECTIVE METHOD; ALKYL-HALIDES; DERIVATIVES; EFFICIENT; QUINAZOLIN-4(3H)-ONES; OXIDATION;
D O I：
10.1055/s-0031-1290098
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel, one-pot, and three-component synthesis of 4(3H)-quinazolinones is described. Benzyl halides are oxidized to aldehydes under mild Kornblum conditions then undergo a three-component reaction with isatoic anhydride and primary amines to produce 4(3H)-quinazolinones in excellent yields.
引用
收藏
页码：85 / 88
页数：4
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