A fast, simple, and reproducible automated synthesis of [18F]FPyKYNE-c(RGDyK) for αvβ3 receptor positron emission tomography imaging

被引：16
|
作者：
Valdivia, Ana C. [1 ]
Estrada, Miriam [1 ]
Hadizad, Tayebeh [1 ]
Stewart, Duncan J. [1 ,2 ,3 ]
Beanlands, Rob S. [1 ,2 ,3 ]
DaSilva, Jean N. [1 ,2 ,3 ]
机构：
[1] Univ Ottawa, Inst Heart, Natl Cardiac PET Ctr, Ottawa, ON K1Y 4W7, Canada
[2] Univ Ottawa, Div Cardiol, Dept Med, Ottawa, ON K1Y 4W7, Canada
[3] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON K1Y 4W7, Canada
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2012年 / 55卷 / 02期
关键词：
av ss 3 integrin receptors; 18F-labeling; 18F]-FPyKYNE; c(iRGDyK); PET; BRAIN-TUMOR ANGIOGENESIS; RGD PEPTIDE; F-18-LABELED RGD; CLICK CHEMISTRY; BREAST-CANCER; IN-VIVO; EXPRESSION; MICROPET; F-18; F-18-GALACTO-RGD;
D O I：
10.1002/jlcr.1948
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
[18?F]FPyKYNE-c(RGDyK) was successfully synthesized by the Cu(I) catalyzed Huisgen 1,3-dipolar cycloaddition of alkynes to azides using [18?F]FPyKYNE as a prosthetic group in an overall radiochemical yield of 12%18% (decay-corrected) and >99.5% chemical and radiochemical purities in 125?min including quality control. This simple, fully automated two-step, two-reactor approach consists of a quick and convenient purification of the prosthetic group using silica gel cartridges and its subsequent use for the labeling of the azido-c(RGDyK) peptide via click chemistry.
引用
收藏
页码：57 / 60
页数：4
相关论文
共 50 条
  • [41] Synthesis and evaluation of 18F -labeled CJ-042794 for imaging prostanoid EP4 receptor expression in cancer with positron emission tomography
    Zhang, Zhengxing
    Lau, Joseph
    Kuo, Hsiou-Ting
    Zhang, Chengcheng
    Colpo, Nadine
    Benard, Francois
    Lin, Kuo-Shyan
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (10) : 2094 - 2098
  • [42] Research progress of 18F labeled small molecule positron emission tomography (PET) imaging agents
    Zhang, Mingliang
    Li, Shufeng
    Zhang, Hang
    Xu, Haiwei
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 205
  • [43] In vivo evaluation of [18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography
    Barthel, H
    Wilson, H
    Collingridge, DR
    Brown, G
    Osman, S
    Luthra, SK
    Brady, F
    Workman, P
    Price, PM
    Aboagye, EO
    BRITISH JOURNAL OF CANCER, 2004, 90 (11) : 2232 - 2242
  • [44] Imaging Chronic Tuberculous Lesions Using Sodium [18F]Fluoride Positron Emission Tomography in Mice
    Ordonez, Alvaro A.
    DeMarco, Vincent P.
    Klunk, Mariah H.
    Pokkali, Supriya
    Jain, Sanjay K.
    MOLECULAR IMAGING AND BIOLOGY, 2015, 17 (05) : 609 - 614
  • [45] Preparation and biodistribution of [18F]FP2OP as myocardial perfusion imaging agent for positron emission tomography
    Mou, Tiantian
    Jing, Huihui
    Yang, Wenjiang
    Fang, Wei
    Peng, Cheng
    Guo, Feng
    Zhang, Xianzhong
    Pang, Yan
    Ma, Yunchuan
    BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (03) : 1312 - 1320
  • [46] Imaging Chronic Tuberculous Lesions Using Sodium [18F]Fluoride Positron Emission Tomography in Mice
    Alvaro A. Ordonez
    Vincent P. DeMarco
    Mariah H. Klunk
    Supriya Pokkali
    Sanjay K. Jain
    Molecular Imaging and Biology, 2015, 17 : 609 - 614
  • [47] Positron Emission Tomography Imaging of Autotaxin in Thyroid and Breast Cancer Models Using [18F]PRIMATX
    Litchfield, Marcus
    Wuest, Melinda
    Glubrecht, Daryl
    Briard, Emmanuelle
    Auberson, Yves P.
    McMullen, Todd P. W.
    Brindley, David N.
    Wuest, Frank
    MOLECULAR PHARMACEUTICS, 2021, 18 (09) : 3352 - 3364
  • [48] 18F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging
    Zhang, Shuting
    Wang, Xiao
    He, Yong
    Ding, Rui
    Liu, Hang
    Xu, Jingli
    Feng, Man
    Li, Guixia
    Wang, Ming
    Peng, Cheng
    Qi, Chuanmin
    BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (07) : 2394 - 2401
  • [49] Imaging the Vesicular Acetylcholine Transporter in Schizophrenia: A Positron Emission Tomography Study Using [18F]-VAT
    Weinstein, Jodi J.
    Moeller, Scott J.
    Perlman, Greg
    Gil, Roberto
    Van Snellenberg, Jared X.
    Wengler, Kenneth
    Meng, Jiayan
    Slifstein, Mark
    Abi-Dargham, Anissa
    BIOLOGICAL PSYCHIATRY, 2024, 96 (05) : 352 - 364
  • [50] In vivo evaluation of [18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography
    H Barthel
    H Wilson
    D R Collingridge
    G Brown
    S Osman
    S K Luthra
    F Brady
    P Workman
    P M Price
    E O Aboagye
    British Journal of Cancer, 2004, 90 : 2232 - 2242
12345