Transcriptional regulation of long-term potentiation

被引：12

作者：

Bliim, Nicola ^{[1
]}

Leshchyns'ka, Iryna ^{[1
]}

Sytnyk, Vladimir ^{[1
]}

Janitz, Michael ^{[1
]}

机构：

[1] Univ New South Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia

来源：

NEUROGENETICS | 2016年 / 17卷 / 04期

关键词：

Long-termpotentiation; Non-coding RNAs; Gene expression; Synaptic plasticity; Transcriptome; CAMP-RESPONSIVE ELEMENT; CENTRAL-NERVOUS-SYSTEM; IMMEDIATE-EARLY GENE; GENOME-WIDE ANALYSIS; SYNAPTIC PLASTICITY; PROTEIN-KINASE; RNA-SEQ; NONCODING RNAS; INTERMEDIATE-TERM; C-FOS;

D O I：

10.1007/s10048-016-0489-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Long-term potentiation (LTP), the persistent strengthening of synapses following high levels of stimulation, is a form of synaptic plasticity that has been studied extensively as a possible mechanism for learning and memory formation. The strengthening of the synapse that occurs during LTP requires cascades of complex molecular processes and the coordinated remodeling of pre-synaptic and post-synaptic neurons. Despite over four decades of research, our understanding of the transcriptional mechanisms and molecular processes underlying LTP remains incomplete. Identification of all the proteins and non-coding RNA transcripts expressed during LTP may provide greater insight into the molecular mechanisms involved in learning and memory formation.

引用

页码：201 / 210

页数：10

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