Surface modification and drug delivery applications of MoS2 nanosheets with polymers through the combination of mussel inspired chemistry and SET-LRP

Mussel inspired chemistry is a promising surface modification tool, which has attracted great research attention for different applications owing to its universality and interest properties. In this work, a rather simple and efficient method for the surface modification of MoS2 nanosheets with copolymers was achieved through the combination of mussel inspired chemistry and single-electron transfer living radical polymerization (SET-LRP) using 2-methacryloyloxyethyl phosphorylcholine (MPC) and itaconic acid (IA) as the monomers. The obtained MoS2-PDA-poly(MPC-IA) nanocomposites were ascertained by a series of characterization techniques, such as nuclear magnetic resonance spectroscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis and X-ray photoelectron spectroscopy. Moreover, the MoS2-PDA-poly(MPC-IA) nanocomposites showed enhanced dispersbility and great biocompatibility. The results implied that the MoS2-PDA-poly(MPC-IA) nanocomposites showed great potential in the field of biomedical science. In this work, the drug loading capability and controlled drug release behavior towards CDDP have been investigated. The drug loading in MoS2-PDA-poly(MPC-IA) composites is as high as 55.26%. All of these above results suggested that the combination of mussel inspired chemistry and SET-LRP is a facile and efficient strategy for fabrication of MoS2 based polymer nanocomposites with great potential application in biomedical fields. (C) 2017 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.