The diversity of vacA and cagA genes of Helicobacter pylori in East Asia

被引:28
作者
Zhou, W
Yamazaki, S
Yamakawa, A
Ohtani, M
Ito, Y
Keida, Y
Higashi, H
Hatakeyama, M
Si, JM
Azuma, T [1 ]
机构
[1] Fukui Med Univ, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
[2] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Clin Res Inst, Hangzhou 310027, Peoples R China
[3] Okinawa Chubu Hosp, Div Internal Med, Okinawa, Japan
[4] Hokkaido Univ, Inst Med Genet, Div Mol Oncol, Sapporo, Hokkaido, Japan
[5] Hokkaido Univ, Grad Sch Sci, Sapporo, Hokkaido, Japan
来源
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2004年 / 40卷 / 01期
基金
日本学术振兴会;
关键词
vacA; cagA; duodenal ulcer; chronic gastritis; Helicobacter pylori;
D O I
10.1016/S0928-8244(03)00299-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
It has been reported that Helicobacter pylori infection with the type I strain, which expresses the VacA and CagA antigens, is associated with duodenal ulcer. We examined the diversity of vacA and cagA genes in 143 isolates obtained from patients with duodenal ulcer or chronic gastritis in East Asia (two different areas of Japan, Fukui and Okinawa, and also in Hangzhou, China) by polymerase chain reaction (PCR) and sequence analysis. Diversities of cagA and vacA genes were detected in East Asia. The prevalence of cagA-positive H. pylori was significantly different between Fukui and Okinawa (P = 0.0032). The prevalence of Western type CagA was significantly higher in Okinawa than in Fukui (P < 0.0001). However, there was no significant association between the genotype of cagA and clinical outcome. In Japan, the predominant vacA genotype was slc/mlb. In contrast, in Hangzhou, the predominant vacA genotype was s1c/m2, and they were all East Asian CagA-positive. These findings suggest that a distinct distribution of the vacA and cagA genotypes is present in East Asia, regardless of clinical outcome. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:81 / 87
页数:7
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