Enhanced angular domain optical imaging by background scattered light subtraction from a deviated laser source

被引:1
作者
Vasefi, Fartash [1 ]
Chapman, Glenn H. [1 ]
Chan, Paulman [1 ]
Kaminska, Bozena [1 ]
Pfeiffer, Nick [1 ]
机构
[1] Simon Fraser Univ, Sch Engn Sci, Burnaby, BC V5A 1S6, Canada
来源
OPTICAL INTERACTIONS WITH TISSUE AND CELLS XIX | 2008年 / 6854卷
关键词
optical tomography; angular domain Imaging; diode lasers; tissue optics; digital image processing;
D O I
10.1117/12.764651
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Imaging structures within a turbid medium using Angular Domain Imaging (ADI) employs angular filter array aligned to a laser source to separate ballistic and quasi-ballistic photons from the highly scattered light by means of angular filtration. The angular filter consists of a high aspect ratio linear array of silicon micromachined tunnels, 51 micron wide by 10 mm long with a 0.29 degree acceptance angle. At heavy scattering ratios of > 1E7:1 image detectability declines due to the non-uniform scattered background light fraction still within the acceptance angle. This scattered signal can be separated out by introducing a wedge prism to deviate the laser source where it enters the medium by an angle slightly larger than the acceptance angle. This creates a second image consisting of pure scattered photons with the filtration characteristics of the angular filter, and a pixel by pixel correspondence to the fully scattered illumination emitted from the medium. Experiments used an 808 nm laser diode, collimated to an 8 x 1 mm line of light, entering a 5 cm thick medium with a scattering ratio of > 1E6:1, with a wedge prism creating a 0.44 degree deviation. Digitally subtracting the deviated scattered signal from the original image significantly reduced the scattered background and enhanced image contrast. We can obtain images with scattering ratios at least 40 times more than our previous scattering limits. The contrast level can be increased from 0.04 of the total dynamic range to over 0.50, depending on test phantom object location, which results in higher definition and visibility of our micro-scale test structures in the turbid medium.
引用
收藏
页数:12
相关论文
共 16 条
[1]  
BEUTHAN J, 1993, MED OPTICAL TOMOGRAP, P263
[2]   Imaging the body with diffuse optical tomography [J].
Boas, DA ;
Brooks, DH ;
Miller, EL ;
DiMarzio, CA ;
Kilmer, M ;
Gaudette, RJ ;
Zhang, Q .
IEEE SIGNAL PROCESSING MAGAZINE, 2001, 18 (06) :57-75
[3]   Sources of absorption and scattering contrast for near-infrared optical mammography [J].
Cerussi, AE ;
Berger, AJ ;
Bevilacqua, F ;
Shah, N ;
Jakubowski, D ;
Butler, J ;
Holcombe, RF ;
Tromberg, BJ .
ACADEMIC RADIOLOGY, 2001, 8 (03) :211-218
[4]   Multispectral angular domain optical tomography in scattering media with argon and diode laser sources [J].
Chan, Paulman K. Y. ;
Vasefi, Fartash ;
Chapman, Glenn H. ;
Kaminska, Bozena ;
Pfeiffer, Nick .
OPTICAL INTERACTIONS WITH TISSUE AND CELLS XVIII, 2007, 6435
[5]   Angular domain imaging of objects within highly scattering media using silicon micromachined collimating arrays [J].
Chapman, GH ;
Trinh, M ;
Pfeiffer, N ;
Chu, G ;
Lee, D .
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 2003, 9 (02) :257-266
[6]  
CHAPMAN GH, 2006, P SPIE, V6084
[7]  
CHEN K, 2003, Patent No. 20030062268
[8]   Time-resolved fluorescence and photon migration studies in biomedical and model random media [J].
Das, BB ;
Liu, F ;
Alfano, RR .
REPORTS ON PROGRESS IN PHYSICS, 1997, 60 (02) :227-292
[9]  
Fercher AF, 2003, REP PROG PHYS, V66, P239, DOI 10.2184/lsj.31.635
[10]   Optical coherence tomography [J].
Fujimoto, JG .
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE IV PHYSIQUE ASTROPHYSIQUE, 2001, 2 (08) :1099-1111