Enuresis and urinary incontinence in children and adolescents with spinal muscular atrophy

被引:17
作者
von Gontard, A
Laufersweiler-Plass, C
Backes, M
Zerres, K
Rudnik-Schöneborn, S
机构
[1] Univ Cologne, Dept Child & Adolescent Psychiat, D-50938 Cologne, Germany
[2] Univ Aachen, Rhein Westfal TH Aachen, Dept Human Genet, D-5100 Aachen, Germany
关键词
spinal muscular atrophy; urinary incontinence; nocturnal enuresis; voiding postponement; stress incontinence; dysfunctional voiding;
D O I
10.1046/j.1464-410X.2001.02341.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objective To assess the rate and type of urinary incontinence in a large sample of children and adolescents with spinal muscular atrophy (SMA), a genetic disorder characterized by loss of motor function caused by anterior horn degeneration. Patients, subjects and methods The study included 96 severely incapacitated patients with SMA (aged 6.0-18.11 years) who were examined in detail, including a structured interview (Kinder-DIPS). the Child Behaviour Checklist (CBCL) and a specific questionnaire for urinary incontinence. They were compared with two control groups of unaffected siblings and normal children. Results In all. 29%, of the patients were wet at night and/or during the day; mostly younger children with SMA types I and II only were affected. The results of the interview were more reliable than the CBCL. The specific questionnaire revealed a variety of possible functional and neurogenic forms of wetting, including nocturnal enuresis, voiding postponement, dysfunctional voiding, stress, symptomatic (urinary tract infections, UTIs) and neurogenic incontinence. Many patients were constipated, soiled or had UTIs. The rate of behavioural problems was twice as high (32%) as normal (15%: CBCL). Conclusion Children with SMA have it high rate of urinary incontinence which is often overlooked, and not diagnosed and treated adequately. These problems should be addressed routinely by paediatricians in children referred to paediatric urological specialists.
引用
收藏
页码:409 / 413
页数:5
相关论文
共 24 条
[1]  
Achenbach T.M., 1991, MANUAL CHILD BEHAV C
[2]  
Byrd RS, 1996, PEDIATRICS, V98, P414
[3]   The survival motor neuron protein in spinal muscular atrophy [J].
Coovert, DD ;
Le, TT ;
McAndrew, PE ;
Strasswimmer, J ;
Crawford, TO ;
Mendell, JR ;
Coulson, SE ;
Androphy, EJ ;
Prior, TW ;
Burghes, AHM .
HUMAN MOLECULAR GENETICS, 1997, 6 (08) :1205-1214
[4]  
FERGUSSON DM, 1986, PEDIATRICS, V78, P884
[5]  
FOXMAN B, 1986, PEDIATRICS, V77, P482
[6]   MICTURITION HABITS AND INCONTINENCE IN 7-YEAR-OLD SWEDISH SCHOOL ENTRANTS [J].
HELLSTROM, AL ;
HANSON, E ;
HANSSON, S ;
HJALMAS, K ;
JODAL, U .
EUROPEAN JOURNAL OF PEDIATRICS, 1990, 149 (06) :434-437
[7]  
HJALMAS K, 1992, SCAND J UROL NEPHROL, P39
[8]  
HJALMAS K, 1992, SCAND J UROL NEPHROL, P1
[9]   ENURESIS IN 7-YEAR-OLD CHILDREN [J].
JARVELIN, MR ;
VIKEVAINENTERVONEN, L ;
MOILANEN, I ;
HUTTUNEN, NP .
ACTA PAEDIATRICA SCANDINAVICA, 1988, 77 (01) :148-153
[10]  
LARGO RH, 1978, SCHWEIZ MED WSCHR, V108, P155