Rapid tumor regression from PD-1 inhibition after anti-CD19 chimeric antigen receptor T-cell therapy in refractory diffuse large B-cell lymphoma

被引:40
作者
Hill, Brian T. [1 ]
Roberts, Zachary J. [2 ]
Xue, Allen [2 ]
Rossi, John M. [2 ]
Smith, Mitchell R. [1 ,3 ]
机构
[1] Cleveland Clin Fdn, Taussig Canc Inst, 9500 Euclid Ave, Cleveland, OH 44195 USA
[2] Kite, Santa Monica, CA USA
[3] George Washington Canc Ctr, Washington, DC USA
关键词
D O I
10.1038/s41409-019-0657-3
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
引用
收藏
页码:1184 / 1187
页数:4
相关论文
共 14 条
[1]  
[Anonymous], 2017, YESC AX CIL PACK INS
[2]  
[Anonymous], BLOOD
[3]   Revised response criteria for malignant lymphoma [J].
Cheson, Bruce D. ;
Pfistner, Beate ;
Juweid, Malik E. ;
Gascoyne, Randy D. ;
Specht, Lena ;
Horning, Sandra J. ;
Coiffier, Bertrand ;
Fisher, Richard I. ;
Hagenbeek, Anton ;
Zucca, Emanuele ;
Rosen, Steven T. ;
Stroobants, Sigrid ;
Lister, T. Andrew ;
Hoppe, Richard T. ;
Dreyling, Martin ;
Tobinai, Kensei ;
Vose, Julie M. ;
Connors, Joseph M. ;
Federico, Massimo ;
Diehl, Volker .
JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (05) :579-586
[4]   PD-1 blockade modulates chimeric antigen receptor (CAR)-modified T cells: refueling the CAR [J].
Chong, Elise A. ;
Melenhorst, J. Joseph ;
Lacey, Simon F. ;
Ambrose, David E. ;
Gonzalez, Vanessa ;
Levine, Bruce L. ;
June, Carl H. ;
Schuster, Stephen J. .
BLOOD, 2017, 129 (08) :1039-1041
[5]   Characterization of anti-CD19 chimeric antigen receptor (CAR) T cell-mediated tumor microenvironment immune gene profile in a multicenter trial (ZUMA-1) with axicabtagene ciloleucel (axi-cel, KTE-C19). [J].
Galon, Jerome ;
Rossi, John ;
Turcan, Sarah ;
Danan, Corinne ;
Locke, Frederick Lundry ;
Neelapu, Sattva Swarup ;
Miklos, David Bernard ;
Bartlett, Nancy L. ;
Jacobson, Caron Alyce ;
Braunschweig, Ira ;
Oluwole, Olalekan O. ;
Siddiqi, Tanya ;
Lin, Yi ;
Timmerman, John ;
Reagan, Patrick Michael ;
Lekakis, Lazaros J. .
JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
[6]   Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associated With High Serum Interleukin-15 Levels [J].
Kochenderfer, James N. ;
Somerville, Robert P. T. ;
Lu, Tangying ;
Shi, Victoria ;
Bot, Adrian ;
Rossi, John ;
Xue, Allen ;
Goff, Stephanie L. ;
Yang, James C. ;
Sherry, Richard M. ;
Klebanoff, Christopher A. ;
Kammula, Udai S. ;
Sherman, Marika ;
Perez, Arianne ;
Yuan, Constance M. ;
Feldman, Tatyana ;
Friedberg, Jonathan W. ;
Roschewski, Mark J. ;
Feldman, Steven A. ;
McIntyre, Lori ;
Toomey, Mary Ann ;
Rosenberg, Steven A. .
JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (16) :1803-1813
[7]   Current concepts in the diagnosis and management of cytokine release syndrome [J].
Lee, Daniel W. ;
Gardner, Rebecca ;
Porter, David L. ;
Louis, Chrystal U. ;
Ahmed, Nabil ;
Jensen, Michael ;
Grupp, Stephan A. ;
Mackall, Crystal L. .
BLOOD, 2014, 124 (02) :188-195
[8]   Nivolumab in Patients With Relapsed or Refractory Hematologic Malignancy: Preliminary Results of a Phase Ib Study [J].
Lesokhin, Alexander M. ;
Ansell, Stephen M. ;
Armand, Philippe ;
Scott, Emma C. ;
Halwani, Ahmad ;
Gutierrez, Martin ;
Millenson, Michael M. ;
Cohen, Adam D. ;
Schuster, Stephen J. ;
Lebovic, Daniel ;
Dhodapkar, Madhav ;
Avigan, David ;
Chapuy, Bjoern ;
Ligon, Azra H. ;
Freeman, Gordon J. ;
Rodig, Scott J. ;
Cattry, Deepika ;
Zhu, Lili ;
Grosso, Joseph F. ;
Garelik, M. Brigid Bradley ;
Shipp, Margaret A. ;
Borrello, Ivan ;
Timmerman, John .
JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (23) :2698-+
[9]   Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial [J].
Locke, Frederick L. ;
Ghobadi, Armin ;
Jacobson, Caron A. ;
Miklos, David B. ;
Lekakis, Lazaros J. ;
Oluwole, Olalekan O. ;
Lin, Yi ;
Braunschweig, Ira ;
Hill, Brian T. ;
Timmerman, John M. ;
Deol, Abhinav ;
Reagan, Patrick M. ;
Stiff, Patrick ;
Flinn, Ian W. ;
Farooq, Umar ;
Goy, Andre ;
McSweeney, Peter A. ;
Munoz, Javier ;
Siddiqi, Tanya ;
Chavez, Julio C. ;
Herrera, Alex F. ;
Bartlett, Nancy L. ;
Wiezorek, Jeffrey S. ;
Navale, Lynn ;
Xue, Allen ;
Jiang, Yizhou ;
Bot, Adrian ;
Rossi, John M. ;
Kim, Jenny J. ;
Go, William Y. ;
Neelapu, Sattva S. .
LANCET ONCOLOGY, 2019, 20 (01) :31-42
[10]   Phase 1 Results of ZUMA-1: A Multicenter Study of KTE-C19 Anti-CD19 CAR T Cell Therapy in Refractory Aggressive Lymphoma [J].
Locke, Frederick L. ;
Neelapu, Sattva S. ;
Bartlett, Nancy L. ;
Siddiqi, Tanya ;
Chavez, Julio C. ;
Hosing, Chitra M. ;
Ghobadi, Armin ;
Budde, Lihua E. ;
Bot, Adrian ;
Rossi, John M. ;
Jiang, Yizhou ;
Xue, Allen X. ;
Elias, Meg ;
Aycock, Jeff ;
Wiezorek, Jeff ;
Go, William Y. .
MOLECULAR THERAPY, 2017, 25 (01) :285-295