Isoniazid metabolism and hepatotoxicity

被引：171

作者：

Wang, Pengcheng ^{[1
]}

Pradhan, Komal ^{[1
]}

Zhong, Xiao-bo ^{[2
]}

Ma, Xiaochao ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Pharm, Dept Pharmaceut Sci, Ctr Pharmacogenet, Pittsburgh, PA 15261 USA

[2] Univ Connecticut, Sch Pharm, Dept Pharmaceut Sci, Storrs, CT 06269 USA

来源：

ACTA PHARMACEUTICA SINICA B | 2016年 / 6卷 / 05期

关键词：

Isoniazid; Metabolism; Hepatotoxicity; Anti-tuberculosis; N-Acetyltransferase; 2; Amidase; ARYLAMINE N-ACETYLTRANSFERASES; INDUCED LIVER-INJURY; TOXIC HYDRAZINO METABOLITES; ISONICOTINIC-ACID HYDRAZIDE; DRUG-INDUCED HEPATOTOXICITY; S-TRANSFERASE M1; OXIDATIVE STRESS; ANTITUBERCULOSIS DRUGS; GENETIC POLYMORPHISMS; PLASMA-CONCENTRATIONS;

D O I：

10.1016/j.apsb.2016.07.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury. (C) 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

引用

页码：384 / 392

页数：9

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