Hepatocellular carcinoma: clinical significance of signal heterogeneity in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging

被引:26
作者
Fujita, Nobuhiro [1 ]
Nishie, Akihiro [1 ]
Kubo, Yuichiro [2 ]
Asayama, Yoshiki [1 ]
Ushijima, Yasuhiro [1 ]
Takayama, Yukihisa [3 ]
Moirta, Koichiro [1 ]
Shirabe, Ken [4 ]
Aishima, Shinichi [2 ]
Honda, Hiroshi [1 ]
机构
[1] Kyushu Univ, Dept Clin Radiol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
[2] Kyushu Univ, Dept Anat Pathol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
[3] Kyushu Univ, Dept Mol Imaging & Diag, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
[4] Kyushu Univ, Dept Surg & Sci, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan
关键词
Hepatocellular carcinoma; Hepatocarcinogenesis; Magnetic resonance imaging; Gadoxetic acid; Organic anion transporting polypeptide 8; GD-EOB-DTPA; SUPERPARAMAGNETIC IRON-OXIDE; FOCAL LIVER-LESIONS; IMAGES; PREDICTION; INTENSITY; GENE;
D O I
10.1007/s00330-014-3349-9
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objectives To clarify the relationship between the biological behaviour of hepatocellular carcinomas (HCCs) and their signal intensity in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging with a special focus on the signal heterogeneity. Methods A total of 68 patients with 70 pathologically proven HCCs were enrolled. On the basis of the signal intensity in the hepatobiliary phase, the lesions were classified into three groups: group 1, homogeneous hypointensity (n=44); group 2, heterogeneous hyperintensity (n=20); and group 3, homogeneous hyperintensity (n=6). The clinicopathological findings were compared among the three groups. Results The tumour size and the serum level of protein induced by vitamin K absence or antagonist-II (PIVKA-II) were significantly higher in group 2 compared to group 1 (p=0.0155, p=0.0215, respectively) and compared to group 3 (p=0.0330, p=0.0220, respectively). The organic anion transporting polypeptide 8 (OATP8) expression in group 2 and group 3 was significantly higher than in group 1 (p<0.0001, p<0.0001, respectively). Group 2 showed a significantly lower disease-free survival rate compared to group 1 (p=0.0125), and group 2 was an independent prognostic factor for disease-free survival (p=0.0308). Conclusions HCCs in the hepatobiliary phase that are heterogeneously hyperintense on gadoxetic acid-enhanced MR imaging have more malignant potential than other types of HCCs.
引用
收藏
页码:211 / 220
页数:10
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