Mammalian heme peroxidases: From molecular mechanisms to health implications

被引:452
作者
Davies, Michael J. [1 ,2 ]
Hawkins, Clare L. [1 ]
Pattison, David I. [1 ]
Rees, Martin D. [1 ]
机构
[1] Heart Res Inst, Camperdown, NSW, Australia
[2] Univ Sydney, Fac Med, Sydney, NSW 2006, Australia
关键词
D O I
10.1089/ars.2007.1927
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A marked increase in interest has occurred over the last few years in the role that mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil peroxidase, and lactoperoxidase, may play in both disease prevention and human pathologies. This increased interest has been sparked by developments in our understanding of polymorphisms that control the levels of these enzymes, a greater understanding of the basic chemistry and biochemistry of the oxidants formed by these species, the development of specific biomarkers that can be used in vivo to detect damage induced by these oxidants, the detection of active forms of these peroxidases at most, if not all, sites of inflammation, and a correlation between the levels of these enzymes and a number of major human pathologies. This article reviews recent developments in our understanding of the enzymology, chemistry, biochemistry and biologic roles of mammalian peroxidases and the oxidants that they generate, the potential role of these oxidants in human disease, and the use of the levels of these enzymes in disease prognosis.
引用
收藏
页码:1199 / 1234
页数:36
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